Results 181 to 190 of about 33,360 (259)

Tolvaptan vs Fluid Restriction in Moderate-Profound Hyponatremia: An Open-Label Randomized Clinical Trial. [PDF]

J Clin Endocrinol Metab
Warren AM, Grossmann M, Hoermann R, Lin R, Zajac JD, Russell N.   +5 more
europepmc   +1 more source

Dissecting the Spectrum of Rare BRAF Mutations in Melanoma: A Nation‐Wide Study by the Italian Melanoma Intergroup (IMI)

Pigment Cell &Melanoma Research, Volume 39, Issue 3, May 2026.
In a large multicentre Italian cohort (14,081 melanoma cases from 19 centres), rare BRAF mutations (~2%) showed survival and response to targeted therapy comparable to V600E/K. Functional modeling indicates that variants, particularly near codon 600, can induce constitutive activation, supporting expanded BRAF genotyping to identify additional patients
Bruna Dalmasso, Maria Chiara Scaini, Laura Cendron, Monica Rodolfo, Ilaria Mattavelli, Elena Tamborini, Francesca Collina, Gerardo Ferrara, Gabriele Madonna, Carlo Cota, Elisa Melucci, Stefania Tommasi, Martina Ubaldi, Roberta Depenni, Andrea Carugno, Riccardo Marconcini, Laura Orgiano, Maurizio Lombardo, Simona Sola, Cristina Pellegrini, Francesca Castiglione, Matteo Gasparotto, Alireza Jorkesh, Stefania Pellegrini, Edoardo Raposio, Andrea Boutros, Enrica Teresa Tanda, Michele Guida, Pietro Quaglino, Giuseppe Palmieri, Daniela Massi, Paolo Antonio Ascierto, Francesco Spagnolo, Mario Mandalà, Chiara Menin, Paola Ghiorzo, Lorenza Pastorino, Italian Melanoma Intergroup, Lorenza Di Guardo, Roberto Patuzzo, Maria Colombino, Simone Ribero, Rebecca Senetta, Gabriele Roccuzzo, Maria Concetta Fargnoli, Cesare Massone, Maria Lentini, Giuseppe Giuffrè, Teresa Troiani, Denise Morotti, Miriam Paone   +50 more
wiley   +1 more source

Omega Nucleic Acids (ΩNA), Ultimate Nucleic Acids for Future Technology. [PDF]

Molecules
Hamada S, Murayama K, Takezawa Y, Toyoda R, Kuzuya A.   +4 more
europepmc   +1 more source

Clearing the Noise: Seasonal Dynamics of Endophytic Bacteria in Fagus sylvatica Leaves Revealed by Application of PNA Clamps

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT The characterization of the seasonal dynamics of endophytic bacteria in beech leaves can be hindered by co‐amplification of chloroplast and mitochondrial plant DNA. This study applies established peptide nucleic acid (PNA) clamps to suppress host‐derived amplification while resolving bacterial succession across the vegetative season ...
Irene Giubilei, Silvia Turco, Antonella Cardacino, Lovely Mahawar, Benedicte Riber Albrectsen, Angelo Mazzaglia   +5 more
wiley   +1 more source

Rethinking the electrographical boundaries of status epilepticus: controversies and paradoxes of the ictal-interictal continuum. [PDF]

Front Neurol
Bosque-Varela P, Jannone-Pedro N, Machegger L, Trinka E, Tsalouchidou PE.   +4 more
europepmc   +1 more source

Transient analysis and engineering of bacterial metabolic pathways using cell-penetrating peptide-peptide nucleic acid conjugates. [PDF]

Microb Cell Fact
Kawabuchi Y, Kobayashi S, Yu J, Kasai G, Kobe M, Suo R, Itoi S, Sode K, Muraoka T, Asano R, Mori T.   +10 more
europepmc   +1 more source

Human α2‐Macroglobulin: Architecture, Mechanisms, and Functional Implications

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Visual representation of human α2‐macroglobulin in its native and induced conformations. General functions associated with the native form (green), the induced form (white), and both conformations (light red) are indicated. ABSTRACT α2‐Macroglobulin (α2M) is a large glycoprotein and one of the most abundant proteins found in the plasma of vertebrates ...
Pietro de Carvalho Andrade, Tales Alexandre Costa‐Silva, Gisele Monteiro   +2 more
wiley   +1 more source

Bio-orthogonal chemistry-based strategy to Turn-OFF CRISPR-Cas9 activity in solution and live cells. [PDF]

NAR Mol Med
Pandit B, Vangaveti S, Sentre JF, McClain I, Fuchs G, Royzen M.   +5 more
europepmc   +1 more source

Pacific Decadal Oscillation Modulates an Interdecadal Trans‐Pacific Dry‐Wet Seesaw in East Asian and North American Semi‐Arid Regions

Geophysical Research Letters, Volume 53, Issue 8, 28 April 2026.
Abstract Semi‐arid regions are expanding globally through divergent pathways: in East Asia (EA) via drying of semi‐humid lands, while in North America (NA) through wetting of arid areas. This interdecadal dry‐wet reversal across the Pacific has remained mechanistically unclear.
Shanshan Wang, Xinya Shu, Jianping Huang, Jinfei Sun, Fuxing Shi   +4 more
wiley   +1 more source

Do Magnesium Ions Have Similar Effects as Calcium Ions on Resting Membrane Potential? [PDF]

Membranes (Basel)
Hana A, Kim Y, Bidros J, Neglia K, Cooper RL.   +4 more
europepmc   +1 more source