Results 91 to 100 of about 76,979 (321)

Changes in the Features of Invasive Pneumococcal Disease after Introduction of the Seven-valent Pneumococcal Conjugate Vaccine in a Regional Core Hospital of Kochi, Japan [PDF]

, 2015
Since the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7) in 2007, invasive pneumococcal disease has declined, but the incidence of Streptococcus pneumoniae serotype 19A has risen worldwide.
Akane Kanazawa, Chiho Tokorodani, Hidehiko Maruyama, Hirokazu Watanabe, Hiroyuki Miyahara, Kiyoshi Kikkawa, Mari Miyazawa, Ritsuo Nishiuchi, Yuka Iwasaki, Yusei Nakata, Yusuke Shigemitsu   +10 more
core   +1 more source

Mutations in RNU4ATAC Are Associated With Chilblain‐Like Lesions and Enhanced Type I Interferon Signalling

European Journal of Immunology, Volume 55, Issue 5, May 2025.
Mutations in the non‐coding RNA gene RNU4ATAC are associated with growth restriction and complications related to antibody deficiency. Here, we report that innate immune dysfunction is a previously unrecognised feature of this disorder. In particular, painful chilblain‐like lesions are common in RNU4ATAC patients and are linked to dysregulated type I ...
Nic Robertson, Aakash Joshi, Francesca Ritchie, Ina Schim van der Loeff, David Royan, Angela L. Duker, Gillian I. Rice, Michael B. Bober, Sahar Mansour, David I. Campbell, Mary Brennan, Lindsay Brown, Laura Jones, Eleri Williams, Andrew P. Jackson, Yanick J. Crow   +15 more
wiley   +1 more source

Prevalence, spatial distribution and determinants of complete childhood pneumococcal conjugate vaccination in Ethiopia: spatial and multilevel analyses

BMC Public Health
Introduction Pneumococcal disease is a serious global public health concern. The primary causative agent of severe illnesses such as pneumonia, meningitis, acute otitis media, and bacteremia is the pneumococcus bacterium.
Tadesse Tarik Tamir, Bewuketu Terefe, Mulugeta Wassie, Belayneh Shetie Workneh, Alebachew Ferede Zegeye   +4 more
doaj   +1 more source

Invasive pneumococcal disease in relation to vaccine type serotypes

Human Vaccines & Immunotherapeutics, 2019
Since 1983 the world has been introduced to four vaccines combating disease caused by Streptococcus pneumoniae bacteria. However, despite vaccination programs disease caused by S.
Paeton L. Wantuch, Fikri Y. Avci
doaj   +1 more source

Invasive Serotype 35B Pneumococci Including an Expanding Serotype Switch Lineage, United States, 2015–2016

Emerging Infectious Diseases, 2017
We used whole-genome sequencing to characterize 199 nonvaccine serotype 35B pneumococcal strains that caused invasive pneumococcal disease (IPD) in the United States during 2015–2016 and related these findings to previous serotype 35B IPD data obtained ...
Sopio Chochua, Benjamin J. Metcalf, Zhongya Li, Hollis Walker, Theresa Tran, Lesley McGee, Bernard Beall   +6 more
doaj   +1 more source

Efficacy and effectiveness of extended-valency pneumococcal conjugate vaccines [PDF]

Korean Journal of Pediatrics, 2014
The 7-valent pneumococcal protein conjugate vaccine (PCV7) has been shown to be highly efficacious against invasive pneumococcal diseases and effective against pneumonia and in reducing otitis media. The introduction of PCV7 has resulted in major changes
Hyunju Lee, Eun Hwa Choi, Hoan Jong Lee
doaj   +1 more source

Pneumococcal conjugate vaccine : what you need to know [PDF]

Pneumococcal conjugate vaccine can prevent pneumococcal disease.Pneumococcal disease refers to any illness caused by pneumococcal bacteria. These bacteria can cause many types of illnesses, including pneumonia, which is an infection of the lungs ...

core   +3 more sources

Occupationally Relevant Zinc‐ and Copper‐Containing Metal Fumes Inhibit Human THP‐1 Macrophage TNF and IL‐6 Responses to Bacterial Stimuli

Global Challenges, Volume 9, Issue 5, May 2025.
Metal workers have an increased risk of severe pneumonia due to metal fume exposure. In this study, zinc oxide (ZnO) and copper oxide (CuO) particles are found to inhibit specific anti‐bacterial macrophage responses, which may substantially contribute to impaired lung immunity.
Jan Steffens, Sabrina Michael, Katharina Kuth, Henner Hollert, Miriam Du Marchie Sarvaas, Andrijana Nesic, Thomas Kraus, Ralf Baumann   +7 more
wiley   +1 more source

Hopf-bifurcation analysis of pneumococcal pneumonia with time delays [PDF]

arXiv, 2019
In this paper, a mathematical model of pneumococcal pneumonia with time delays is proposed. The stability theory of delay differential equations is used to analyze the model. The results show that the disease-free equilibrium is asymptotically stable if the control reproduction ratio R0 is less than unity and unstable otherwise.
arxiv  

The Impact of Vaccine Hesitancy on Epidemic Spreading [PDF]

arXiv, 2021
The COVID-19 pandemic has devastated the world in an unprecedented way, causing enormous loss of life. Time and again, public health authorities have urged people to become vaccinated to protect themselves and mitigate the spread of the disease. However, vaccine hesitancy has stalled vaccination levels in the United States.
arxiv