Results 41 to 50 of about 4,927,702 (244)

Meningococcal and pneumococcal meningitis in Northern Ghana [PDF]

, 2008
Despite improvements in technology, treatments and understanding of how bacterial meningitis develops, the disease remains a potentially life-threatening emergency capable of causing significant morbidity and mortality. N. meningitidis, S.
Forgor, Abdulai Adams
core   +1 more source

Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]

, 2012
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Greenwood, Brian M, Wattiaux Andre, Stephen R C Howie, Effua Usuf, Sambou Sana, Plumb Ian D., Uchendu, Uchendu, Wattiaux, Andre, Maria Deloria Knoll, Howie Stephen R. C., Saha, Debasish, Ian D Plumb, Philip C Hill, Howie, Stephen RC, Ikumapayi Usman N., Mackenzie Grant A., Lee Ellen, Jasseh, Momodou, Greenwood Brian M., Sana Sambou, Debasish Saha, Akinsola, Bolanle, Ellen Lee, Hill, Philip C, Brian M Greenwood, Jasseh Momodou, Adegbola, Richard A, Plumb, Ian D, Hill Philip C., Akinsola Bolanle, Kebba Touray, Uchendu Uchendu, Baldeh Ignatius, Usman N Ikumapayi, Ikumapayi, Usman N, Touray, Kebba, Levine, Orin S, Orin S Levine, Usuf Effua, Lee, Ellen, Ignatius Baldeh, Richard A Adegbola, Bolanle Akinsola, Saha Debasish, Momodou Jasseh, Sambou, Sana, Levine Orin S., Grant A Mackenzie, Knoll, Maria Deloria, Andre Wattiaux, Baldeh, Ignatius, Mackenzie, Grant A, Knoll Maria Deloria, Adegbola Richard A., Touray Kebba, Usuf, Effua   +55 more
core   +1 more source

Hospitalization rates for pneumococcal disease in Brazil, 2004 - 2006

Revista de Saúde Pública, 2011
OBJECTIVE: To estimate hospitalization rates for pneumococcal disease based on the Brazilian Hospital Information System (SIH). METHODS: Descriptive study based on the Hospital Information System of Brazilian National Health System data from January 2004
Hillegonda Maria Dutilh Novaes, Ana Marli Christovam Sartori, Patricia Coelho de Soárez   +2 more
doaj   +1 more source

Development and Validation of a Sensitive and Robust Multiplex Antigen Capture Assay to Quantify Streptococcus pneumoniae Serotype-Specific Capsular Polysaccharides in Urine

mSphere, 2022
Streptococcus pneumoniae is a major cause of community-acquired pneumonia (CAP) in young children, older adults, and those with immunocompromised status.
Gowrisankar Rajam, Yuhua Zhang, Joseph M. Antonello, Rebecca J. Grant-Klein, Lauren Cook, Reshma Panemangalore, Huy Pham, Stephanie Cooper, Thomas D. Steinmetz, Jennifer Nguyen, Mathias W. Pletz, Grit Barten-Neiner, Rocio D. Murphy, Leonard J. Rubinstein, Katrina M. Nolan   +14 more
doaj   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013–2015)

BMC Infectious Diseases
Background Pneumococcal disease caused by Streptococcus pneumoniae is an important cause of morbidity and mortality across all ages, particularly in younger children and older adults. Here, we describe pneumococcal disease hospitalizations at Ministry of
Saravanan S. R. Sundaramurthy, Kristen E. Allen, Mark A. Fletcher, Kok Fui Liew, Boekhtiar Borhanuddin, Mohammad Ali, Graciela Morales, Bradford Gessner, Jerusha Naidoo, Jo Southern   +9 more
doaj   +1 more source

Multiple Colonization with S. pneumoniae before and after Introduction of the Seven-Valent Conjugated Pneumococcal Polysaccharide Vaccine [PDF]

, 2010
Background: Simultaneous carriage of more than one strain of Streptococcus pneumoniae promotes horizontal gene transfer events and may lead to capsule switch and acquisition of antibiotic resistance. We studied the epidemiology of cocolonization with S.
Hinds Jason, Brugger, Silvio D., Frey, Pascal, Hinds, Jason, Brugger Silvio D., Frey Pascal, Silvio D Brugger, Silvio D. Brugger, Hinds, J, Brugger, SD, Aebi, S, Jason Hinds, Kathrin Mühlemann, Mühlemann, K, Suzanne Aebi, Mühlemann Kathrin, Aebi Suzanne, Aebi, Suzanne, Mühlemann, Kathrin, Pascal Frey, Frey, P   +20 more
core   +2 more sources

A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015

BMC Infectious Diseases
Background To estimate the burden of invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media before and after inclusion of the 13-valent pneumococcal vaccine (PCV13) into Taiwan’s Childhood Immunization Program in ...
Ting-An Yen, Jhong-Lin Wu, Chi-Chuan Wang, Ling-Ya Huang, See-Hwee Yeo, Dony Patel, Cindy Thiow Koon Lim, Hung-Wei Lin, Eriko Yamada, Isaya Sukarom   +9 more
doaj   +1 more source

Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making

Vaccines, 2023
Pneumococcal disease remains one of the major causes of severe disease in both children and adults. Severe disease may be prevented by pneumococcal polysaccharide and conjugate vaccines, which currently cover more than 20 serotypes.
Kay Choong See
doaj   +1 more source