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Pathogenesis of pneumococcal infection [PDF]

open access: bronzeJournal of Medical Microbiology, 2000
The pathogenesis of pneumococcal infection is a complex interplay between pneumococcal virulence determinants and the host immune response. Molecular studies have considerably advanced our knowledge and understanding of the precise structures and functions of the different determinants and their pathogenic roles. This review describes the mechanisms by
Stephen H. Gillespie   +1 more
openaire   +4 more sources

New Vaccines for the Prevention of Pneumococcal Infections

open access: diamondEmerging Infectious Diseases, 1996
Streptococcus pneumoniae is a major cause of acute otitis media, pneumonia, bacteremia, and meningitis. Because in recent years antibiotic-resistant pneumococcal strains have been emerging throughout the world, vaccination against pneumococcal infections
Helena Käyhty, Juhani Eskola
doaj   +2 more sources

THE CHEMOSEROTHERAPY OF EXPERIMENTAL PNEUMOCOCCAL INFECTION [PDF]

open access: bronzeJournal of Experimental Medicine, 1915
1. A single small dose of ethylhydrocuprein (optochin base), which by itself has practically no protective effect against experimental pneumococcal infection in mice, is capable of increasing the threshold value of the type homologous antipneumococcus serum at least fifty times. 2. This effect is proportionately many times greater than a
H. F. Moore
openaire   +4 more sources

Mathematical modelling long-term effects of replacing Prevnar7 with Prevnar13 on invasive pneumococcal diseases in England and Wales [PDF]

open access: yes, 2012
England and Wales recently replaced the 7-valent pneumococcal conjugate vaccine (PCV7) with its 13-valent equivalent (PCV13), partly based on projections from mathematical models of the long-term impact of such a switch compared to ceasing pneumococcal ...
A Melegaro   +21 more
core   +17 more sources

Adult pneumococcal vaccination – new opportunities

open access: yesFamily Medicine & Primary Care Review, 2023
Pneumococcal infections (Streptococcus pneumoniae) remain a significant epidemiological problem globally. Although an invasive pneumo-coccal disease (IPD), which includes meningitis, sepsis and pneumonia with bacteremia, is the most severe form of ...
ERNEST KUCHAR   +13 more
doaj   +1 more source

Clearance of mixed biofilms of Streptococcus pneumoniae and methicillin-susceptible/resistant Staphylococcus aureus by antioxidants N-acetyl-l-cysteine and cysteamine

open access: yesScientific Reports, 2022
Biofilm-associated infections are of great concern because they are associated with antibiotic resistance and immune evasion. Co-colonization by Staphylococcus aureus and Streptococcus pneumoniae is possible and a threat in clinical practice.
Julio Sempere   +7 more
doaj   +1 more source

Transmission factors and exposure to infections at work and invasive pneumococcal disease

open access: yesAmerican Journal of Industrial Medicine, Volume 66, Issue 1, Page 65-74, January 2023., 2023
Abstract Background Working in close contacts with coworkers or the general public may be associated with transmission of invasive pneumococcal disease (IPD). We investigated whether crowded workplaces, sharing surfaces, and exposure to infections were factors associated with IPD.
Kjell Torén   +4 more
wiley   +1 more source

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