Results 41 to 50 of about 43,698 (190)

The Biology of Pneumococcal Infection [PDF]

Pediatric Research, 1997
For 100 y, the study of the molecular mechanism of pneumococcal infection has richly rewarded biomedical science and pediatrics. More recently, a framework has emerged for how the pathogen engineers colonization, invasion of the lung and bloodstream, and finally, entry into the brain.
openaire   +2 more sources

Impact of preceding flu-like illness on the serotype distribution of pneumococcal pneumonia.

PLoS ONE, 2014
BackgroundEven though the pathogenicity and invasiveness of pneumococcus largely depend on capsular types, the impact of serotypes on post-viral pneumococcal pneumonia is unknown.Methods and findingsThis study was performed to evaluate the impact of ...
Joon Young Song, Moon H Nahm, Hee Jin Cheong, Woo Joo Kim   +3 more
doaj   +1 more source

The Saudi Thoracic Society pneumococcal vaccination guidelines-2016

Annals of Thoracic Medicine, 2016
Streptococcus pneumoniae (pneumococcus) is the leading cause of morbidity and mortality worldwide. Saudi Arabia is a host to millions of pilgrims who travel annually from all over the world for Umrah and the Hajj pilgrimages and are at risk of developing
N S Alharbi, A M Al-Barrak, M S Al-Moamary, M O Zeitouni, M M Idrees, M O Al-Ghobain, A A Al-Shimemeri, Mohamed S Al-Hajjaj   +7 more
doaj   +1 more source

PNEUMOCOCCAL INFECTIONS AS MODERN THREAT TO HEALTH OF EARLY AGE CHILDREN: VACCINATION PROSPECTS

Педиатрическая фармакология, 2009
Wide spread of pneumococcal carriage, resistance to human organism defenses and ease of developing antibiotic resistance makes pneumococcus an extremely significant pathogen.
E.F. Lukushkina
doaj   +2 more sources

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Non-specific effects of pneumococcal conjugate vaccines: clinical significance and molecular mechanisms

Журнал инфектологии
Pneumococcal conjugate vaccines (PCVs) are widely used to prevent infections caused by Streptococcus pneumoniae, but evidence shows that they also exert clinically relevant nonspecific effects. This review summarizes current data on the impact of PCVs on
A. U. Mirzova, K. V. Zhdanov, S. M. Kharit   +2 more
doaj   +1 more source

Optimal age targeting for pneumococcal vaccination in older adults; a modelling study

Nature Communications, 2023
Vaccination against invasive pneumococcal disease is recommended for older adults but the optimal age group to target has not been determined and may vary by epidemiological setting.
Deus Thindwa, Samuel Clifford, Jackie Kleynhans, Anne von Gottberg, Sibongile Walaza, Susan Meiring, Todd D. Swarthout, Elizabeth Miller, Peter McIntyre, Nick Andrews, Zahin Amin-Chowdhury, Norman Fry, Kondwani C. Jambo, Neil French, Samanta Cristine Grassi Almeida, Shamez N. Ladhani, Robert S. Heyderman, Cheryl Cohen, Maria Cristina de Cunto Brandileone, Stefan Flasche   +19 more
doaj   +1 more source

Global Control of Pneumococcal Infections by Pneumococcal Vaccines

Tropical Medicine and Health, 2014
Streptococcus pneumoniae is a major worldwide cause of morbidity and mortality. Pneumococcal carriage is considered to be an important source of horizontal spread of this pathogen within the community. Pneumococcal conjugate vaccine (PCV) is capable of inducing serotype-specific antibodies in sera of infants, and has been suggested to reduce ...
Oishi, Kazunori, Tamura, Kazuyo, Akeda, Yukihiro   +2 more
openaire   +3 more sources

Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response—A Randomized, Placebo‐Controlled Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used by solid organ transplant recipients. Although it is known that MMF suppresses immune responses, its exact effects on specific vaccinations have not been investigated yet. Mucosal vaccinations are increasingly used, such as a cholera vaccination consisting of two oral immunizations ...
Boukje C. Eveleens Maarse, Aliede E. in 't Veld, Hendrika W. Grievink, Manon A.A. Jansen, Matthijs Moerland   +4 more
wiley   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source