Results 41 to 50 of about 383,894 (265)

Burden of pneumococcal disease in children in Cuba before the introduction of a novel pneumococcal conjugate vaccine

Journal of Global Health Reports, 2019
# Background The Cuban heptavalent conjugate pneumococcal vaccine will be introduced for children beginning in 2020. We estimated the burden of pneumococcal cases and deaths in children 1-59 months in 2015.
Nivaldo Linares-Pérez, Brian Wahl, Misladys Rodriguez, Gilda Toraño, María E. Toledo-Romaní   +4 more
doaj   +1 more source

Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study

Clinical Infectious Diseases, 2017
Upper airway pneumococcal colonization density among children hospitalized with World Health Organization–defined pneumonia was associated with microbiologically confirmed pneumococcal pneumonia (MCPP).
H. Baggett, Nora L. Watson, M. Deloria Knoll, W. A. Brooks, D. Feikin, L. Hammitt, S. Howie, K. Kotloff, O. Levine, S. Madhi, D. Murdoch, J. Scott, D. Thea, M. Antonio, J. Awori, V. Baillie, A. DeLuca, A. Driscoll, J. Duncan, B. Ebruke, D. Goswami, Melissa M Higdon, R. Karron, D. Moore, Susan C. Morpeth, J. Mulindwa, Daniel E Park, W. Paveenkittiporn, Barameht Piralam, Christine Prosperi, S. Sow, Milagritos D. Tapia, K. Zaman, S. Zeger, K. O'Brien, K L O S M D D R A N A J Nicholas Wei L L M M E R A M O L K F D D Fancourt Fu H H Wangeci Kagucia K Li P, K. O, O. L., M. K, D. F, A. D., A. D., N. Fancourt, W. Fu, L. H., M. H., E. Wangeci Kagucia, R. K, Mengying Li, D. P., C. P., Zhenke Wu, S. Z., N. W., Jane Crawley, D R M, W. B., H. Endtz, K. Z., D. G., L. Hossain, Y. Jahan, H. Ashraf, S. C H, B. E, M. A., J. McLellan, E. Machuka, Arifin Shamsul, Syed M. A. Zaman, G. Mackenzie, J. G S, J. A., S C M, A. Kamau, S. Kazungu, M. Ominde, K. K., M. T., S. S, M. Sylla, Boubou Tamboura, U. Onwuchekwa, N. Kourouma, A. Touré, S A M, D P M, P. Adrian, V. B., Locadiah Kuwanda, Azwifarwi Mudau, M. Groome, N. Mahomed, H. B, S. Thamthitiwat, S. Maloney, C. Bunthi, J. Rhodes, Pongpun Sawatwong, P. Akarasewi, D. T, L. Mwananyanda, J. Chipeta, P. Seidenberg, J. Mwansa, Somwe Wa Somwe, G. Kwenda, T. Anderson, Joanne L. Mitchell   +108 more
semanticscholar   +1 more source

Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia

Frontiers in Immunology, 2018
Excessive activation of neutrophils results in the release of neutrophil elastase (NE), which leads to lung injury in severe pneumonia. Previously, we demonstrated a novel immune subversion mechanism involving microbial exploitation of this NE ability ...
H. Domon, K. Nagai, T. Maekawa, M. Oda, Daisuke Yonezawa, Wataru Takeda, Takumi Hiyoshi, Hikaru Tamura, M. Yamaguchi, S. Kawabata, Y. Terao   +10 more
semanticscholar   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The anticipated severity of a "1918-like" influenza pandemic in contemporary populations: the contribution of antibacterial interventions. [PDF]

PLoS ONE, 2012
Recent studies have shown that most of deaths in the 1918 influenza pandemic were caused by secondary bacterial infections, primarily pneumococcal pneumonia.
Yu-Wen Chien, Bruce R Levin, Keith P Klugman   +2 more
doaj   +1 more source

IL-17 can be protective or deleterious in murine pneumococcal pneumonia

PLoS Pathogens, 2018
Streptococcus pneumoniae is the major bacterial cause of community-acquired pneumonia, and the leading agent of childhood pneumonia deaths worldwide. Nasal colonization is an essential step prior to infection.
N. Ritchie, Ryan Ritchie, H. K. Bayes, T. Mitchell, T. Evans   +4 more
semanticscholar   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

A model for predicting bacteremia in patients with community-acquired pneumococcal pneumonia: a retrospective observational study

BMC Pulmonary Medicine, 2018
Background Pneumococcal pneumonia causes high morbidity and mortality among adults. This study aimed to identify risk factors for bacteremic pneumococcal pneumonia, and to construct a prediction model for the development of bacteremia in patients with ...
Yasuyoshi Washio, Akihiro Ito, Shogo Kumagai, Tadashi Ishida, Akio Yamazaki   +4 more
doaj   +1 more source

Regionally Compartmentalized Resident Memory T Cells Mediate Naturally Acquired Protection Against Pneumococcal Pneumonia

Mucosal Immunology, 2017
As children age, they become less susceptible to the diverse microbes causing pneumonia. These microbes are pathobionts that infect the respiratory tract multiple times during childhood, generating immunological memory.
N. Smith, Gregory A Wasserman, Fadie T. Coleman, Kristie L. Hilliard, Kazuko Yamamoto, Kazuko Yamamoto, E. Lipsitz, R. Malley, Hans Dooms, Matthew R. Jones, L. Quinton, J. Mizgerd   +11 more
semanticscholar   +1 more source

A Systematic Review of Studies Published between 2016 and 2019 on the Effectiveness and Efficacy of Pneumococcal Vaccination on Pneumonia and Invasive Pneumococcal Disease in an Elderly Population

Pathogens, 2020
Adult vaccination is high on the agenda in many countries. Two different vaccines are available for the prevention of pneumococcal disease in adults: a 23-valent polysaccharide vaccine (PPV23), and a 13-valent conjugated vaccine (PCV13). The objective of
Jacob Dag Berild, B. Winje, D. Vestrheim, H. Slotved, P. Valentiner-Branth, A. Roth, Jann Storsäter   +6 more
semanticscholar   +1 more source