Results 51 to 60 of about 31,112 (177)
ABSTRACT Purpose The primary aim was to conduct a longitudinal pharmacoepidemiological study on the dispensing patterns of the influenza and pneumococcal vaccines in a section of the private healthcare sector in South Africa in the presence of the COVID‐19 vaccine to document the dispensing of these two respiratory vaccines alongside COVID‐19 vaccines.
I. Truter +4 more
wiley +1 more source
Updates in COPD Management: From Inflammatory Pathways to Targeted Therapies
COPD is a heterogeneous disease driven by overlapping neutrophilic and eosinophilic inflammatory pathways. This review highlights the shift from symptom‐based treatment toward phenotype‐ and biomarker‐directed care. Blood eosinophils, FeNO, and IgE predict corticosteroid responsiveness and identify candidates for biologic therapy.
Sasha Raman +3 more
wiley +1 more source
Are the pneumococcal polysaccharide vaccines effective? Meta-analysis of the prospective trials
The objective was to review the evidence of effectiveness of the polyvalent polysaccharide pneumococcal vaccine from prospective properly randomised controlled trials comparing pneumococcal vaccines with placebo in subjects who are immunocompetent and ...
Lipsky Benjamin A +2 more
doaj +1 more source
ABSTRACT Background Bloodstream infections remain a major cause of mortality among cancer patients. Pathogen surveillance and risk stratification tools are key to improved management. This study describes trends in causative pathogens and explores risk factors for positive blood cultures (PBCs) and post‐infection mortality in cancer patients.
Mathias Holmsgaard Eskesen +7 more
wiley +1 more source
Fulminating pneumococcal septicemia without an obvious focus of infection is very rare in previously immunocompetent children older than two years. Furthermore, pneumatocele formation in pneumococcal pneumonia is uncommon.
Y Aslan +4 more
doaj
BackgroundThe importance of bacterial infections following respiratory syncytial virus (RSV) remains unclear. We evaluated whether variations in RSV epidemic timing and magnitude are associated with variations in pneumococcal disease epidemics and ...
Daniel M Weinberger +4 more
doaj +1 more source
A Machine Learning–Derived Risk Scorecard for Pneumonia Hospitalization in Japanese Old‐Old Adults
In 1 098 404 community‐dwelling Japanese adults aged ≥ 75 years, a 20‐learner Super Learner using routinely collected health checkup and claims data predicted 1‐year pneumonia hospitalization (test‐set AUC 0.823). An independently developed, well‐calibrated 17‐feature scorecard showed AUC 0.786 and a 15.9‐fold low‐to‐high risk gradient; external ...
Akio Shimizu +5 more
wiley +1 more source
Background: Pneumonia remain an important public health problem. The primary objective was to determine the proportion of community-acquired pneumonia that is attributable to Streptococcus pneumoniae infection; secondary objectives were the description ...
Marta Di Pasquale +6 more
doaj +1 more source
BackgroundS. pneumoniae is a leading cause of meningitis morbidity and mortality in the African meningitis belt, but little is known of its contribution to the burden of pneumonia in the region.
Jennifer C Moïsi +8 more
doaj +1 more source
Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber +4 more
wiley +1 more source

