Pneumococcal Vaccines: Past Findings, Present Work, and Future Strategies [PDF]
Vaccines, 2021 The importance of Streptococcus pneumoniae has been well established. These bacteria can colonize infants and adults without symptoms, but in some cases can spread, invade other tissues and cause disease with high morbidity and mortality. The development
Giuliana S. Oliveira +3 more
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Possible Cross-Reactivity between SARS-CoV-2 Proteins, CRM197 and Proteins in Pneumococcal Vaccines May Protect Against Symptomatic SARS-CoV-2 Disease and Death [PDF]
Vaccines, 2020 Various studies indicate that vaccination, especially with pneumococcal vaccines, protects against symptomatic cases of SARS-CoV-2 infection and death.
Robert Root-Bernstein
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Microbiology Spectrum, 2019 Streptococcus pneumoniae is a Gram-Positive pathogen that is a major causative agent of pneumonia, otitis media, sepsis and meningitis across the world.
D. E. Briles +4 more
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Should Pneumococcal Vaccines Eliminate Nasopharyngeal Colonization? [PDF]
mBio, 2016 Streptococcus pneumoniae remains an important human pathogen. For more than 100 years, there have been vaccine efforts to prevent pneumococcal infection. The pneumococcal conjugate vaccines have significantly reduced invasive disease.
Larry S. McDaniel, Edwin Swiatlo
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Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection [PDF]
Vaccines, 2020 Streptococcus pneumoniae is a major pathogen causing pneumonia with over 2 million deaths annually, especially in young children and the elderly. To date, at least 98 different pneumococcal capsular serotypes have been identified. Currently, the vaccines
Malihe Masomian +3 more
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Recent progress in pneumococcal protein vaccines
Frontiers in Immunology, 2023 Pneumococcal infections continue to pose a significant global health concern, necessitating the development of effective vaccines. Despite the progress shown by pneumococcal polysaccharide and conjugate vaccines, their limited coverage and the emergence ...
Sha Li +4 more
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Multi-Valent Protein Hybrid Pneumococcal Vaccines: A Strategy for the Next Generation of Vaccines. [PDF]
Vaccines (Basel), 2021 Streptococcus pneumoniae (Spn) is a bacterial pathogen known to colonize the upper respiratory tract and cause serious opportunistic diseases such as pneumonia, bacteremia, sepsis and meningitis.
Scott NR +3 more
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New Vaccines for the Prevention of Pneumococcal Infections
Emerging Infectious Diseases, 1996 Streptococcus pneumoniae is a major cause of acute otitis media, pneumonia, bacteremia, and meningitis. Because in recent years antibiotic-resistant pneumococcal strains have been emerging throughout the world, vaccination against pneumococcal infections
Helena Käyhty, Juhani Eskola
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Bacterium-like Particles from Corynebacterium pseudodiphtheriticum as Mucosal Adjuvant for the Development of Pneumococcal Vaccines [PDF]
VaccinesPreviously, it was shown that intranasally (i.n.) administered Corynebacterium pseudodiphtheriticum 090104 (Cp) or CP-derived bacterium-like particles (BLPs) improve the immunogenicity of the pneumococcal conjugate vaccine (PCV).
Ramiro Ortiz Moyano +10 more
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Pneumococcal vaccines in China [PDF]
Human Vaccines & ImmunotherapeuticsInvasive pneumococcal disease (IPD) is a serious global public health problem and the leading cause of morbidity and mortality in children and adults in China. Thus, developing and administering pneumococcal vaccines are important for disease prevention.
Shanshan Wang +6 more
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