Results 31 to 40 of about 45,004 (157)

Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]

, 2012
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Adegbola, Richard A, Akinsola, Bolanle, Baldeh, Ignatius, Greenwood, Brian M, Hill, Philip C, Howie, Stephen RC, Ikumapayi, Usman N, Jasseh, Momodou, Knoll, Maria Deloria, Lee, Ellen, Levine, Orin S, Mackenzie, Grant A, Plumb, Ian D, Saha, Debasish, Sambou, Sana, Touray, Kebba, Uchendu, Uchendu, Usuf, Effua, Wattiaux, Andre   +18 more
core   +2 more sources

Origins of T‐cell‐mediated autoimmunity in acquired aplastic anaemia

British Journal of Haematology, Volume 206, Issue 4, Page 1035-1053, April 2025.
Acquired aplastic anaemia (AA) is an autoimmune bone marrow failure disease caused by a cytotoxic T‐cell–mediated attack on haematopoietic stem and progenitor cells (HSPCs). Despite significant progress in understanding T‐cell repertoire alterations in AA, the identification of specific pathogenic T cells remains elusive.
Aura Enache, Shannon A. Carty, Daria V. Babushok   +2 more
wiley   +1 more source

Pneumococcal vaccine and opsonic pneumococcal antibody [PDF]

Journal of Infection and Chemotherapy, 2013
Streptococcus pneumoniae is a major human pathogen responsible for the majority of bacterial pneumonia cases as well as invasive pneumococcal diseases with high mortality and morbidity. Use of conjugate vaccines targeting the pneumococcal capsule has dramatically reduced the incidence of invasive diseases, and there are active efforts to further ...
Robert L. Burton, Joon Young Song, Joon Young Song, M. Allen Moseley, Moon H. Nahm   +4 more
openaire   +3 more sources

Pneumococcal capsular polysaccharide immunity in the elderly. [PDF]

, 2017
Immunity against pneumococcal infections is impaired in older people, and current vaccines are poorly protective against pneumococcal disease in this population.
Boyd AR, Gordon SB, Joint Committee on Vaccination and Immunisation, Lue C, Tomczyk S, Woof JM   +5 more
core   +1 more source

Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: A longitudinal household study [PDF]

, 2005
Background. Natural immunity to Streptococcus pneumoniae is thought to be induced by exposure to S. pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S.
Andrews, N, Ashton, L, Edmunds, J, Gay, N, George, R, Goldblatt, D, Hussain, M, Kayhty, H, Melegaro, A, Miller, E, Pebody, R, Soininen, A, Virta, C   +12 more
core  

Adults aged 65 years and older in South Africa have a responsibility to vaccinate against influenza

Developing World Bioethics, EarlyView.
Abstract In this article, we draw on the thinking about incompleteness and conviviality grounded in Afro‐communitarianism ethics from the Global South to argue that adults aged 65 years and above have a prima facie responsibility to vaccinate against influenza.
Ruach Sarangarajan, Cornelius Ewuoso
wiley   +1 more source

The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions

The FEBS Journal, Volume 292, Issue 6, Page 1480-1499, March 2025.
Vaccination plays a crucial role in mediating protection against infectious diseases, but immune responses to vaccination are highly variable and frequently sub‐optimal in vulnerable populations. Here, we review the latest preclinical and clinical evidence demonstrating that the gut microbiota plays a significant role in regulating immune responses to ...
Charné Rossouw, Feargal J. Ryan, David J. Lynn   +2 more
wiley   +1 more source

The Hajj 2019 Vaccine Requirements and Possible New Challenges [PDF]

, 2019
Each year millions of pilgrims perform the annual Hajj from more than 180 countries around the world. This is one of the largest mass gathering events and may result in the occurrence and spread of infectious diseases.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
core   +1 more source

Insights into pneumococcal pneumonia using lung aspirates and nasopharyngeal swabs collected from pneumonia patients in The Gambia. [PDF]

, 2020
We investigated the pathogenesis of pneumococcal pneumonia using clinical specimens collected for pneumonia surveillance in The Gambia. Lung aspirates and nasopharyngeal swabs from 31 patients were examined by culture, qPCR, whole genome sequencing ...
Dunne, EM, Hinds, J, Hossain, I, Hua, Y, Mackenzie, GA, Manna, S, Mulholland, EK, Ndiaye, M, Ortika, BD, Salaudeen, R, Satzke, C   +10 more
core   +3 more sources

The Efficacy and Safety of Canagliflozin by Frailty Status in Participants of the CANVAS and CREDENCE Trials

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Sodium‐glucose cotransporter 2 (SGLT2) inhibitors have been shown to improve renal and cardiovascular outcomes in patients with type 2 diabetes. Limited evidence exists about the efficacy and safety of SGLT2 inhibitors in patients with frailty. Methods This was a post hoc pooled, participant‐level data analysis of the CANVAS Program
Tu N. Nguyen, Jie Yu, Vlado Perkovic, Meg Jardine, Kenneth W. Mahaffey, Clara K. Chow, Clare Arnott, Richard I. Lindley   +7 more
wiley   +1 more source