Results 141 to 150 of about 49,378 (316)

Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial

American Journal of Hematology, Volume 101, Issue 2, Page 242-254, February 2026.
ABSTRACT Iptacopan is a first‐in‐class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement‐driven diseases. Here we evaluate the efficacy and safety of iptacopan monotherapy in adult patients with primary immune thrombocytopenia (ITP) and primary cold agglutinin disease (CAD). We performed
Alexander Röth, Wilma Barcellini, Christine Ademokun, Junho Jang, Maria Luisa Lozano, David Valcarcel Ferreiras, Cristina Pascual‐Izquierdo, Shripad Chitnis, Sofiya Matviykiv, Alessandra Vitaliti, Chi Chen, Vasiliki Katsanou, Raghav Chawla, Hanny Al‐Samkari   +13 more
wiley   +1 more source

OBSERVATIONS ON THE PHAGOCYTOSIS OF THE PNEUMOCOCCUS BY HUMAN WHOLE BLOOD

Journal of Experimental Medicine, 1930
1. In vitro phagocytic experiments with human blood, antipneumococcus serum, pneumococcus specific soluble substance, and living virulent pneumococci show that there is a definite phagocytic inhibition zone when strong antiserum is used. 2.
H. Ward
semanticscholar   +1 more source

Streptococcus pneumoniae antibiotikum rezisztenciájának geno- és fenotípusos felmérése = Geno-and phenotypic characterisation of antibiotic resistance of Streptococcus pneumoniae [PDF]

, 2009
A legfontosabb projekt az invazív pneumococcusok epidemiológiai felmérése volt. Ez az anyag majdnem teljesen készen áll, utolsó simítások után már csak a cikk megírása van hátra.
Dobay, Orsolya
core  

The ZNF148‐ZEB1‐AS1‐IGF2BP2‐NOD2 Axis Drives Microglial Antipneumococcal Immunity in Bacterial Meningitis

Glia, Volume 74, Issue 2, February 2026.
ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu, Fang Jiang, Xinjie Liu, Ling Li, Ruimei Hu, Meng Dong, Aihua Cao   +6 more
wiley   +1 more source

Unraveling the full impact of SPD_0739: a key effector in S. pneumoniae iron homeostasis

Microbiology Spectrum
Streptococcus pneumoniae is a common member of the nasopharynx commensal microflora and the leading etiological agent of bacterial pneumonia in young children and aging adults.
Edroyal Womack, Melina Antone, Zehava Eichenbaum   +2 more
doaj   +1 more source

Characterization of Streptococcus pneumoniae strains isolated from patients with meningitis before the introduction of pneumococcal conjugate vaccine in Serbia [PDF]

Medicinski Podmladak, 2020
Introduction: Pneumococcal meningitis is a serious disease which affects mostly children ≤ 2 years, adults ≥ 65 years and immunodeficient patients. The introduction of pneumococcal conjugate vaccine (PCV) into immunization programs worldwide has led to a
Milojević Sara, Kekić Dušan, Gajić Ina, Mijač Vera, Opavski Nataša   +4 more
doaj  

Cardio–Renal Diseases Are Independent Risk Factors of Severe Human Metapneumovirus Infection Among Patients Without Chronic Airway Diseases

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT Human metapneumovirus (hMPV) causes mild and self‐limiting disease in adults. However, the risk factors for serious adverse outcomes following hMPV infection in adult patients without preexisting chronic airway diseases remain poorly understood.
Wang Chun Kwok, Isaac Sze Him Leung, Chun Ka Emmanuel Wong, James Chung Man Ho, David Chi Leung Lam, Mary Sau Man Ip, Shuk Man Ngai, Kelvin Kai Wang To, Desmond Yat Hin Yap   +8 more
wiley   +1 more source

Serum antibody responses of juvenile and infant rhesus monkeys injected with Haemophilus influenzae type b and pneumococcus type 6A capsular polysaccharide-protein conjugates [PDF]

, 1984
Rachel Schneerson, John B. Robbins, Chun-Yen Chu, A Sutton, Willie F. Vann, Julie Vickers, W T London, Blanche Curfman, M. C. Hardegree, Joseph Shiloach   +9 more
openalex   +1 more source

Clinical presentation, treatment, and outcome of children with primary intestinal lymphangiectasia: A national retrospective study

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 398-406, February 2026.
Abstract Objectives Primary intestinal lymphangiectasia (PIL) is a very rare disease responsible for protein‐losing enteropathy. There is little published data about treatments efficacy and outcomes. Our main objective was to describe the clinical profile, response to therapy, and outcomes of children with PIL.
Noémie Goret, Cécile Lambe, Emmanuelle Ecochard‐Dugelay, Alexandre Fabre, Alain Dabadie, Aurélie Comte, Julie Rebeuh, Pierre Poinsot, Emilie Chaillou, Haude Clouzeau, Aurélie Sabard, Béatrice Dubern, Stéphanie Willot   +12 more
wiley   +1 more source

Guiding AlphaFold predictions with experimental knowledge to inform dynamics and interactions with VAIRO

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Structural predictions have reached unprecedented accuracy. They leverage sequence‐specific data to capture all potential interactions a sequence has evolved to fulfill. AlphaFold derives information from three sources: learned parameters capturing intrinsic amino acid secondary structure and environment propensity; models of related proteins ...
Josep Triviño, Elisabet Jiménez, Christoph Grininger, Iracema Caballero, Ana Medina, Albert Castellví, Giovanna Petrillo, Fernando Govantes, Theo Sagmeister, Martín Alcorlo, Juan A. Hermoso, Massimo D. Sammito, Kay Diederichs, Tea Pavkov‐Keller, Isabel Usón   +14 more
wiley   +1 more source