Results 21 to 30 of about 69,859 (225)

Fungal colonization with Pneumocystis correlates to increasing chloride channel accessory 1 (hCLCA1) suggesting a pathway for up-regulation of airway mucus responses, in infant lungs [PDF]

, 2014
Fungal colonization with Pneumocystis is associated with increased airway mucus in infants during their primary Pneumocystis infection, and to severity of COPD in adults. The pathogenic mechanisms are under investigation.
Bustamante, Rebeca I., Gallo, Myriam, Hananias, Karime, Iturra, Pablo A., Ponce, Carolina A., Pérez, Francisco J., Rojas, Diego A., Vargas, Sergio L.   +7 more
core   +2 more sources

Immunization with Pneumocystis recombinant KEX1 induces robust and durable humoral responses in immunocompromised non-human primates

Human Vaccines & Immunotherapeutics, 2019
Infection with the opportunistic fungal pathogen, Pneumocystis jirovecii causes life-threatening pneumonia in immunocompromised individuals. In addition to HIV-1 infected patients, individuals at risk of Pneumocystis infection include those receiving ...
Viviana Cobos Jiménez, Whitney Rabacal, Emily Rayens, Karen A. Norris   +3 more
doaj   +1 more source

Detection of Pneumocystis and Morphological Description of Fungal Distribution and Severity of Infection in Thirty-Six Mammal Species

Journal of Fungi, 2023
Pneumocystis spp. are thought to adapt to the lungs of potentially all mammals. However, the full host range, fungal burden and severity of infection are unknown for many species.
Christiane Weissenbacher-Lang, Barbara Blasi, Patricia Bauer, Diana Binanti, Karin Bittermann, Lara Ergin, Carmen Högler, Tanja Högler, Magdalena Klier, Julia Matt, Nora Nedorost, Serenella Silvestri, Daniela Stixenberger, Liang Ma, Ousmane H. Cissé, Joseph A. Kovacs, Amélie Desvars-Larrive, Annika Posautz, Herbert Weissenböck   +18 more
doaj   +1 more source

Scaling-up co-trimoxazole prophylaxis in HIV-exposed and HIV-infected children in high HIV-prevalence countries. [PDF]

, 2007
Co-trimoxazole (trimethoprim-sulfamethoxazole) is a widely available antibiotic that substantially reduces HIV-related morbidity and mortality in both adults and children.
Abdel-Haq, Anglaret, Anglaret, Ansari, Anthony D Harries, Badri, Boerma, Chewe Luo, Chintu, Chintu, Creek, Gill, Graham, Graham, Gretchen Bachman, Grimwade, Manzi, Mermin, Mermin, Mwaungulu, Nathoo, Perez, Ponnet, Rony Zachariah, Ruffini, Stephen M Graham, Thera, Watera, Wiktor, Yazdanpanah, Zachariah, Zachariah, Zachariah, Zachariah   +33 more
core   +2 more sources

Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future. [PDF]

, 2017
The respiratory system consists of an integrated network of organs and structures that primarily function for gas exchange. In mammals, oxygen and carbon dioxide are transmitted through a complex respiratory tract, consisting of the nasal passages ...
Miller, Lisa, Pinkerton, Kent, Royer, Christopher, Schelegle, Edward   +3 more
core   +1 more source

The role of opportunistic pathogens as etiological agents of intrauterine infections

Детские инфекции (Москва), 2019
The study showed a high prevalence of markers of herpesvirus infections among mothers — from 71% to 98% of HSV, EBV and CMV infections and from 29% to 58% of HHV-6 infection.
V. V. Kosenchuk, T. N. Rybalkina, R. E. Boshyan, N. V. Karazhas, M. N. Kornienko, P. A. Veselovsky, M. Yu. Lysenkova, M. S. Savenkova, M. Yu. Ivanova   +8 more
doaj   +1 more source

Single-Cell TCR Sequencing Reveals the Dynamics of T Cell Repertoire Profiling During Pneumocystis Infection

Frontiers in Microbiology, 2021
T cell responses play critical roles in host adaptive immunity against Pneumocystis. However, the dynamics and diversity of the T cell immune repertoire in human immunodeficiency virus (HIV)-negative Pneumocystis pneumonia (PCP) remains unclear.
Hu-Qin Yang, Yi-Shan Wang, Kan Zhai, Zhao-Hui Tong   +3 more
doaj   +1 more source

Increased mortality in hematological malignancy patients with acute respiratory failure from undetermined etiology : a Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologique (Grrr-OH) study [PDF]

, 2016
Background: Acute respiratory failure (ARF) is the most frequent complication in patients with hematological malignancies and is associated with high morbidity and mortality.
Azoulay, Elie, Benoit, Dominique, Bruneel, Fabrice, Contejean, Adrien, Darmon, Michael, Hamidfar, Rebecca, Jourdain, Mercé, Kouatchet, Achille, Lemiale, Virginie, Mayaux, Julien, Meert, Anne-Pascale, Mokart, Djamel, Nyunga, Martine, Perez, Pierre, Pène, Frédéric, Rabbat, Antoine, Renault, Anne, Resche-Rigon, Matthieu, Schlemmer, Benoît, Vincent, François   +19 more
core   +2 more sources

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra, Lujain Ez Eddin, Fatemeh Ahmadi, Atefeh Jafari, Flory T. Muanda   +4 more
wiley   +2 more sources

Analysis of Pneumocystis Transcription Factor Evolution and Implications for Biology and Lifestyle

mBio, 2023
Pneumocystis jirovecii kills hundreds of thousands of immunocompromised patients each year. Yet many aspects of the biology of this obligate pathogen remain obscure because it is not possible to culture the fungus in vitro independently of its host ...
Ryan Ames, Alistair J. P. Brown, Ivana Gudelj, Olga A. Nev   +3 more
doaj   +1 more source