Results 41 to 50 of about 38,988 (220)

Single-Cell TCR Sequencing Reveals the Dynamics of T Cell Repertoire Profiling During Pneumocystis Infection

Frontiers in Microbiology, 2021
T cell responses play critical roles in host adaptive immunity against Pneumocystis. However, the dynamics and diversity of the T cell immune repertoire in human immunodeficiency virus (HIV)-negative Pneumocystis pneumonia (PCP) remains unclear.
Hu-Qin Yang, Yi-Shan Wang, Kan Zhai, Zhao-Hui Tong   +3 more
doaj   +1 more source

Genotypic variation in Pneumocystis jirovecii isolates in Britain

, 2005
Background: Pneumocystis jirovecii is the cause of Pneumocystis pneumonia (PCP) in immunosuppressed humans. Asymptomatic colonisation with P jirovecii may occur in patients with minor immunosuppression or chronic lung disease.
Davies, RJ, Wakefield, AE, Ambrose, HE, Copas, A, Lindley, AR, Miller, RF, Davies, RJO   +6 more
core   +1 more source

Intrinsic Programming of Alveolar Macrophages for Protective Antifungal Innate Immunity Against Pneumocystis Infection

Frontiers in Immunology, 2018
Invasive fungal infections, including Pneumocystis Pneumonia (PcP), remain frequent life-threatening conditions of patients with adaptive immune defects.
Samir P. Bhagwat, Francis Gigliotti, Francis Gigliotti, Jing Wang, Zhengdong Wang, Robert H. Notter, Patrick S. Murphy, Fátima Rivera-Escalera, Jane Malone, Michael B. Jordan, Michael R. Elliott, Michael R. Elliott, Terry W. Wright, Terry W. Wright   +13 more
doaj   +1 more source

Analysis of Pneumocystis Transcription Factor Evolution and Implications for Biology and Lifestyle

mBio, 2023
Pneumocystis jirovecii kills hundreds of thousands of immunocompromised patients each year. Yet many aspects of the biology of this obligate pathogen remain obscure because it is not possible to culture the fungus in vitro independently of its host ...
Ryan Ames, Alistair J. P. Brown, Ivana Gudelj, Olga A. Nev   +3 more
doaj   +1 more source

DEPENDENCE OF DETECTION OF MARKERS OF OPPORTUNISTIC INFECTIONS FROM ADHERENCE TO ANTIRETROVIRAL THERAPY IN CHILDREN BORN BY HIV-INFECTED MATTERS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2018
Aim. To study the dependence of detection of markers of opportunistic infections from afherence to antiretroviral therapy in children born to HIV-infected mothers on the example of herpesvirus infectionsand pneumocystis. Materials and methods. Samples of
T. N. Rybalkina, N. V. Karazhas, P. A. Savinkov, R. E. Boshyan, M. Yu. Lysenkova, M. N. Kornienko, E. M. Burmistrov, P. A. Veselovsky, I. A. Soldatova   +8 more
doaj   +1 more source

CD4+ T-cell independent secondary immune responses to Pneumocystis pneumonia

Frontiers in Immunology, 2016
Pneumocystis pneumonia is a major cause of morbidity and mortality among immunocompromised patients, especially in the context of HIV/AIDS. In the murine model of Pneumocystis pneumonia, CD4+ T-cells are required for clearance of a primary infection of ...
Nicholas M de la Rua, Derrick Richard Samuelson, Tysheena P Charles, David Allen Welsh, Judd E. Shellito   +4 more
doaj   +1 more source

Detection of Pneumocystis and Morphological Description of Fungal Distribution and Severity of Infection in Thirty-Six Mammal Species

Journal of Fungi, 2023
Pneumocystis spp. are thought to adapt to the lungs of potentially all mammals. However, the full host range, fungal burden and severity of infection are unknown for many species.
Christiane Weissenbacher-Lang, Barbara Blasi, Patricia Bauer, Diana Binanti, Karin Bittermann, Lara Ergin, Carmen Högler, Tanja Högler, Magdalena Klier, Julia Matt, Nora Nedorost, Serenella Silvestri, Daniela Stixenberger, Liang Ma, Ousmane H. Cissé, Joseph A. Kovacs, Amélie Desvars-Larrive, Annika Posautz, Herbert Weissenböck   +18 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Improved survival for HIV infected patients with severe Pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy

, 2006
Background: Despite a decline in incidence of Pneumocystis jirovecii pneumonia (PCP), severe PCP continues to be a common cause of admission to the intensive care unit (ICU) where mortality remains high. A study was undertaken to examine the outcome from
Singer, M, Copas, A, Edwards, SG, Miller, RF, Allen, E   +4 more
core   +1 more source

Case Report: Tricho-hepato-enteric syndrome in an infant presented with colorectal ulceration and severe respiratory superinfection

Frontiers in Immunology
IntroductionTricho-hepato-enteric syndrome (THES) is a rare genetic disorder characterized by early-onset intractable diarrhea, intrauterine growth retardation, hair abnormalities, and liver disease during early infancy.
Yuta Narishige, Tomohiro Nakano, Yusuke Hoshi, Kenji Sonota, Hiroki Sakurai, Fumihiko Kakuta, Taku Koizumi, Yoji Sasahara, Daiki Abukawa   +8 more
doaj   +1 more source