Results 41 to 50 of about 61,919 (199)

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Targeting β-glucans, vital components of the Pneumocystis cell wall

Frontiers in Immunology, 2023
β-glucan is the most abundant polysaccharide in the cell wall of Pneumocystis jirovecii, which has attracted extensive attention because of its unique immunobiological characteristics.
Mengyan Wang, Mengyan Wang, Zhongdong Zhang, Xiaotian Dong, Biao Zhu   +4 more
doaj   +1 more source

PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity [PDF]

, 2010
Primacenes, novel ferrocene-primaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active ...
Jiri Gut, Joana Matos, Margaret S Collins, Melanie T Cushion, Nuno Vale, Paula Gomes, Philip J Rosenthal, Rui Moreira   +7 more
core   +1 more source

Efficacy of upadacitinib induction for pediatric inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Objectives Upadacitinib, a second‐generation Janus kinase (JAK) inhibitor, is approved for moderate to severe Crohn's disease (CD) and ulcerative colitis (UC) in adults. Its efficacy in pediatric patients remains unclear, though early reports suggest benefits in refractory inflammatory bowel disease (IBD).
Evan Greenhall, Nina Gautam, Paula Prieto‐Jimenez, Elizabeth Hilow, Ashish Patel, Brad Pasternak   +5 more
wiley   +1 more source

CMV Infection and Lymphopenia: Warning Markers of Pneumocystis Pneumonia in Kidney Transplant Recipients

Transplant International
Pneumocystis pneumonia (PcP) remains life-threatening in kidney transplant recipients (KTR). Our study investigated risk factors one-year before PcP.
Isabelle Eberl, Christine Binquet, Christine Binquet, Adrien Guilloteau, Mathieu Legendre, Frederic Dalle, Frederic Dalle, Lionel Piroth, Lionel Piroth, Lionel Piroth, Claire Tinel, Claire Tinel, Mathieu Blot, Mathieu Blot, Mathieu Blot, Mathieu Blot   +15 more
doaj   +1 more source

Survey of the Transcription Factor Responses of Mouse Lung Alveolar Macrophages to Pneumocystis murina

Pathogens, 2021
Pneumocystis jirovecii is a fungal pathogen that can cause life-threatening infections in individuals who are immunocompromised. Acquired via inhalation, upon entering the respiratory tract, the fungi first encounter innate immune cells such as alveolar ...
Theodore J. Kottom, Kyle Schaefbauer, Eva M. Carmona, Andrew H. Limper   +3 more
doaj   +1 more source

An evolutionary perspective on zinc uptake by human fungal pathogens [PDF]

, 2015
DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 102549/Z/13/Z).Peer reviewedPublisher ...
Wilson, Duncan
core   +1 more source

Upper Airway Obstruction due to Kaposi Sarcoma—Presenting Sign of HIV: Case Report and Review

The Laryngoscope, EarlyView.
This study presents a case of undiagnosed HIV presenting with Kaposi sarcoma (KS) of the head and neck with acute upper airway obstruction (UAO) and provides an updated scoping literature review to examine the patient characteristics, lesion characteristics, interventions, and outcomes of KS cases with UAO from the pharynx, larynx, and/or trachea.
Zachary A. Wykoff, Logan F. McColl, Robert A. Baiocchi, Matthew O. Old   +3 more
wiley   +1 more source

Beyond the First Year: Epidemiology and Management of Late-Onset Opportunistic Infections After Kidney Transplantation

Transplant International
Late opportunistic infections (OI) occurring beyond the first year after kidney transplantation (KT) are poorly described and not targeted by prophylactic strategies. We performed a ten-year retrospective monocentric cohort study describing epidemiology,
V. Esnault, L. Hoisnard, L. Hoisnard, L. Hoisnard, B. Peiffer, V. Fihman, S. Fourati, C. Angebault, C. Angebault, C. Champy, S. Gallien, S. Gallien, P. Attias, A. Morel, P. Grimbert, P. Grimbert, G. Melica, M. Matignon, M. Matignon   +18 more
doaj   +1 more source

Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future. [PDF]

, 2017
The respiratory system consists of an integrated network of organs and structures that primarily function for gas exchange. In mammals, oxygen and carbon dioxide are transmitted through a complex respiratory tract, consisting of the nasal passages ...
Miller, Lisa, Pinkerton, Kent, Royer, Christopher, Schelegle, Edward   +3 more
core   +1 more source