Results 181 to 190 of about 7,584 (199)

Detection of pneumolysin in sputum

Journal of Medical Microbiology, 1999
Western blot detection of the species-specific pneumococcal product, pneumolysin (SPN), was shown to be almost as sensitive as PCR for the non-cultural detection of pneumococci in 27 Streptococcus pneumoniae culture-positive sputa from patients stated to have chest infections. Both techniques were considerably more sensitive than counter-current immuno-
Wheeler J, Freeman R, Steward M, Henderson K, Lee MJS, Piggott NH, Eltringham GJA, Galloway A   +7 more
openaire   +3 more sources

Pneumolysin: A multifunctional pneumococcal virulence factor

Journal of Laboratory and Clinical Medicine, 1998
Pneumolysin (PLY) is a multifunctional pneumococcal virulence factor that appears to augment intrapulmonary growth and dissemination during the early pathogenesis of Streptococcus pneumoniae infection. Through its cytotoxicity to respiratory epithelium and endothelium, PLY disrupts pulmonary tissue barriers that serve as mechanical pulmonary defenses ...
J B, Rubins, E N, Janoff
openaire   +2 more sources

The Biology of Pneumolysin

2014
Cholesterol dependent cytolysins are important in the ability of some bacteria to cause disease in man and animals. Pneumolysin (PLY) plays a key role in the diseases caused by Streptococcus pneumoniae (the pneumococcus). This chapter describes the role of PLY in some of the key process in disease.
Tim J, Mitchell, Catherine E, Dalziel
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Pneumolysin in pneumococcal adherence and colonization

Microbial Pathogenesis, 1998
The universal and highly conserved production of pneumolysin, the major pneumococcal cytolysin, among clinical isolates of Streptococcus pneumoniae and the previously reported association of pneumolysin production with increased pneumococcal adherence to respiratory epithelium in organ cultures suggest that this toxin might be important for ...
J B, Rubins, A H, Paddock, D, Charboneau, A M, Berry, J C, Paton, E N, Janoff   +5 more
openaire   +2 more sources

Relationship of Structure to Function in Pneumolysin

Microbial Drug Resistance, 1997
72447
Andrew, PW, Mitchell, TJ, Morgan, PJ
openaire   +3 more sources

Juglone alleviates pneumolysin-induced human alveolar epithelial cell injury via inhibiting the hemolytic activity of pneumolysin

Antonie van Leeuwenhoek, 2017
Streptococcus pneumoniae (the pneumococcus) is an opportunistic pathogen responsible for several human diseases, including acute otitis media, pneumonia, sepsis and bacterial meningitis, and possesses numerous virulence factors associated with pneumococcal infection and pathogenesis.
Meng, Song, Gejin, Lu, Meng, Li, Xuming, Deng, Jianfeng, Wang   +4 more
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[Research progress in pneumolysin].

Wei sheng wu xue bao = Acta microbiologica Sinica, 2018
Pneumolysin is a multifunctional virulence factor expressed by Streptococcus pneumoniae. Pneumolysin includes 4 domains and is a member of cholesterol-dependent cytolysins. Pneumolysin has extensive cytotoxicity to a range of host cells. Furthermore, pneumolysin can activate complement classical pathway, and induce macrophages and monocytes to produce ...
Wu, Rui, Kui, Nie, Rendong, Fang
openaire   +1 more source

Production and purification of Streptococcus pneumoniae hemolysin (pneumolysin)

Journal of Clinical Microbiology, 1987
Pneumolysin was found to be produced by 112 of 113 clinical isolates of Streptococcus pneumoniae and to be an intracellular hemolysin. A 10-liter-scale fermentor production and purification procedure was developed for this hemolysin. The culture was concentrated by filtration 10 times before centrifugation.
K, Kanclerski, R, Möllby
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Shikonin alleviates the biotoxicity produced by pneumococcal pneumolysin

Life Sciences, 2017
Streptococcus pneumoniae (S. pneumoniae) is a common pathogen that can cause severe infections in humans. Pneumolysin (PLY) is an important virulence trait of S. pneumoniae and has cytotoxicity, genotoxicity and pro-inflammatory activity; it is essential for the pathogenesis of S.
Xiaoran, Zhao, Yonglin, Zhou, Laiying, Wang, Meng, Li, Dongxue, Shi, Dan, Li, Jianfeng, Wang   +6 more
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Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers

Molecular Pharmacology, 2016
Pneumolysin (PLY), an essential virulence factor of Streptococcus pneumoniae (pneumococcus), can penetrate the physical defenses of the host and possesses inflammatory properties. The vital role PLY plays in pneumococcus pathogenesis makes this virulence factor one of the most promising targets for the treatment of pneumococcal infection. Verbascoside (
Xiaoran, Zhao, Hongen, Li, Jianfeng, Wang, Yan, Guo, Bowen, Liu, Xuming, Deng, Xiaodi, Niu   +6 more
openaire   +2 more sources