Results 51 to 60 of about 24,924 (172)

ctDNA Detection of Polyclonal KRAS Resistance in Adagrasib‐Treated NSCLC

Thoracic Cancer, Volume 17, Issue 15, August 2026.
Longitudinal ctDNA monitoring by ddPCR and targeted NGS in an adagrasib‐treated KRASG12C mutant NSCLC patient revealed the emergence of three new KRAS mutations (G12D, G13D, Q61H), indicating polyclonal resistance, approximately 10 weeks before any radiologic progression by RECIST 1.1.
Marion Caumeil, Julie A. Vendrell, Simon Cabello‐Aguilar, Sarah Cavaillon, Quentin Dominique Thomas, Jérôme Solassol   +5 more
wiley   +1 more source

Risk of urinary tract infection with SGLT2 inhibitor initiation in patients with immune‐mediated inflammatory diseases and type 2 diabetes: A target trial emulation using a Japanese hospital‐based claims database

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1310-1321, August 2026.
In this target trial emulation of patients with immune‐mediated inflammatory diseases and type 2 diabetes, SGLT2 inhibitor initiation was not associated with a clear increase in UTI risk versus metformin, including across immunosuppressive therapy strata.
Hiroshi Tsushima, Nobuyuki Yajima, Takashi Nomiyama, Ryoko Sakai, Hisashi Noma, Akira Katagiri, Naoto Tamura   +6 more
wiley   +1 more source

Immune responses of different hosts to Pneumocystis infection

European Respiratory Review
Pneumocystis pneumonia constitutes a critical life-threatening opportunistic infection, where the host's immune response plays a central role in its pathogenesis.
Jun Li, Xiangdong Mu, Haichao Li, Xinmin Liu   +3 more
doaj   +1 more source

A protracted course of Pneumocystis pneumonia in the setting of an immunosuppressed child with GMS-negative bronchoalveolar lavage

Medical Mycology Case Reports, 2016
We report a case of Pneumocystis pneumonia in a 5-year-old male with Trisomy 21 and acute lymphoblastic leukemia. The lack of response to trimethoprim-sulfamethoxazole raised concerns for antimicrobial resistance.
Taylor Eddens, Eunkyung Song, Monica I. Ardura, Jay K. Kolls   +3 more
doaj   +1 more source

pneumonia in a healthy immunocompetent patient: A case report and literature review

SAGE Open Medical Case Reports
Pneumocystis jirovecii pneumonia, typically an opportunistic infection, is commonly associated with risk factors such as low CD4+ lymphocyte count, underlying malignancies, organ transplantation, or immunosuppressive medications.
Houda Rouis, Chirine Moussa, Yoldez Houcine, Ines Zendah, Hamida Kwas, Habib Ghedira, Sonia Maâlej   +6 more
doaj   +1 more source

Update on the diagnosis and treatment of pneumonia

Therapeutic Advances in Respiratory Disease, 2011
Pneumocystis is an opportunistic fungal pathogen that causes an often-lethal pneumonia in immunocompromised hosts. Although the organism was discovered in the early 1900s, the first cases of Pneumocystis pneumonia in humans were initially recognized in ...
Eva M. Carmona, Andrew H. Limper
doaj   +1 more source

Coexistência de infeções oportunistas pulmonares num doente com infeção por vírus da imunodeficiência humana e uma forma persistente de pneumonia por Pneumocystis jirovecii: caso clínico

Revista Portuguesa de Pneumologia, 2013
Resumo: Como é sabido, nos doentes com infeção por vírus da imunodeficiência humana (VIH) existe um alto risco de ocorrência de infeções oportunistas (IO), tais como as infeções por Pneumocystis jirovecii, um agente patogénico com distribuição mundial ...
D. Ponces Bento, F. Esteves, O. Matos, A.C. Miranda, F. Ventura, C. Araújo, K. Mansinho   +6 more
doaj   +1 more source

Risk Factors for Breakthrough Pneumocystis carinii Pneumonia on Aerosol Pentamidine Prophylaxis

Canadian Respiratory Journal, 1995
OBJECTIVE: To identify baseline characteristics of human immunodeficiency virus (HIV)-infected individuals on aerosol pentamidine for Pneumocystis carinii prophylaxis that are predictive of subsequent breakthrough Pneumocystis carinii pneumonia (PCP).
RA McIvor, AR Rachlis, P Berger, LR Lee Pack, Charles K Chan   +4 more
doaj   +1 more source

Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study

BMC Infectious Diseases, 2009
Background In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation.
Shimizu Yasuo, Sunaga Noriaki, Dobashi Kunio, Fueki Makoto, Fueki Naoto, Makino Sohei, Mori Masatomo   +6 more
doaj   +1 more source

Pneumocystis pneumonia.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2000
No Abstract.
openaire   +2 more sources