Results 171 to 180 of about 4,319 (202)

Design, Synthesis, and Antimalarial Evaluation of New Spiroacridine Derivatives. [PDF]

Antibiotics (Basel)
Cavalcanti MAT, Albino SL, Menezes KJDS, de Araújo WJS, Campos FFGR, Dos Reis MML, Morais I, Duarte DMFA, Nascimento IJDS, Rodrigues-Junior VDS, Nogueira F, Nogueira F, Moura RO.   +12 more
europepmc   +1 more source

The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer's disease. [PDF]

EMBO J
Xiong W, Xu K, Sun JK, Liu S, Zhao B, Shi J, Herrup K, Chow HM, Lu L, Li J.   +9 more
europepmc   +1 more source

8-Aminoguanine and its actions in the metabolic syndrome. [PDF]

Sci Rep
Jackson EK, Gillespie DG, Mi Z, Birder LA, Tofovic SP.   +4 more
europepmc   +1 more source

RNA degradation in human mitochondria: the journey is not finished. [PDF]

Hum Mol Genet
Santonoceto G, Jurkiewicz A, Szczesny RJ.   +2 more
europepmc   +1 more source

Purine nucleoside phosphorylase inhibition is an effective approach for the treatment of chemical hemorrhagic cystitis. [PDF]

JCI Insight
Wolf-Johnston A, Ikeda Y, Zabbarova I, Kanai AJ, Bastacky S, Moldwin R, Stern JN, Jackson EK, Birder LA.   +8 more
europepmc   +1 more source

PNPASE Regulates RNA Import into Mitochondria [PDF]

Cell, 2010
RNA import into mammalian mitochondria is considered essential for replication, transcription, and translation of the mitochondrial genome but the pathway(s) and factors that control this import are poorly understood. Previously, we localized polynucleotide phosphorylase (PNPASE), a 3' --> 5' exoribonuclease and poly-A polymerase, in the mitochondrial ...
Yavuz Oktay, Samuel W French, J Michael Mccaffery   +2 more
exaly   +5 more sources

PNPASE and RNA trafficking into mitochondria [PDF]

Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2012
The mitochondrial genome encodes a very small fraction of the macromolecular components that are required to generate functional mitochondria. Therefore, most components are encoded within the nuclear genome and are imported into mitochondria from the cytosol.
Carla M Koehler, Michael A Teitell
exaly   +3 more sources

Regulation and functions of bacterial PNPase [PDF]

Wiley Interdisciplinary Reviews RNA, 2016
Polynucleotide phosphorylase (PNPase) is an exoribonuclease that catalyzes the processive phosphorolytic degradation of RNA from the 3′‐end. The enzyme catalyzes also the reverse reaction of polymerization of nucleoside diphosphates that has been implicated in the generation of heteropolymeric tails at the RNA 3′‐end. The enzyme is widely conserved and
Federica Briani, Thomas Carzaniga, Gianni Dehò   +2 more
exaly   +4 more sources

Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase) [PDF]

Journal of Molecular and Cellular Cardiology, 2017
Cardiovascular disease is the primary cause of mortality for individuals with type 2 diabetes mellitus. During the diabetic condition, cardiovascular dysfunction can be partially attributed to molecular changes in the tissue, including alterations in microRNA (miRNA) interactions.
Quincy A Hathaway
exaly   +3 more sources

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RNase E biomolecular condensates stimulate PNPase activity

2022
AbstractBacterial Ribonucleoprotein bodies (BR-bodies) play an essential role in organizing RNA degradation via liquid-liquid phase separation in the cytoplasm of bacteria. BR-bodies mediate multi-step mRNA decay through the concerted activity of the endoribonuclease RNase E coupled with the 3’-5’ exonuclease Polynucleotide Phosphorylase (PNPase).
Michael Collins, Dylan T. Tomares, Jared M. Schrader, W. Seth Childers   +3 more
openaire   +1 more source