Results 261 to 270 of about 48,174 (296)
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Current Opinion in Nephrology and Hypertension, 2001
Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
K, Endlich, W, Kriz, R, Witzgall
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Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
K, Endlich, W, Kriz, R, Witzgall
openaire +2 more sources
TGFβ1-dependent podocyte dysfunction
Current Opinion in Nephrology and Hypertension, 2013The glomerular filtration barrier is a unique structure characterized by a specialized framework of podocytes. Transforming growth factor-β1 (TGFβ1) upregulation occurs in virtually all chronic kidney diseases and is associated with podocyte injury and proteinuria. This review is aimed at describing the latest advances made in the understanding of TGFβ-
Michal, Herman-Edelstein +2 more
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Journal of Cellular Physiology, 2018
Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be initiating event in the development of diabetic nephropathy (DN).
Tao Zhang +6 more
semanticscholar +1 more source
Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be initiating event in the development of diabetic nephropathy (DN).
Tao Zhang +6 more
semanticscholar +1 more source
Podocyte regeneration: who can become a podocyte?
The American journal of pathology, 2013This Commentary highlights the article by Pippin et al that showed that renin lineage cells may enhance glomerular regeneration by serving as progenitors for glomerular epithelial cells in glomerular disease characterized by podocyte depletion.
Florian, Grahammer +2 more
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Targeting podocyte-associated diseases☆
Advanced Drug Delivery Reviews, 2010Injury to the podocytes is the initiating cause of many renal diseases, leading to proteinuria with possible progression to end-stage renal disease. Podocytes are highly specialized cells, with an important role in maintaining the glomerular filtration barrier and producing growth factors for both mesangial cells and endothelial cells.
Leeuwis, J.W. +4 more
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Podocytes, glucose and insulin
Current Opinion in Nephrology and Hypertension, 2010In the last decade the importance of the podocyte in maintaining the integrity of the glomerular filtration barrier and prevention of albuminuria has become obvious. The leading cause of renal failure in the developed world is diabetic nephropathy. This has a defined natural history of progressive albuminuria.
Welsh, Gavin I, Coward, Richard J M
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Current Opinion in Nephrology and Hypertension, 2009
The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets.
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The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets.
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Experimental Cell Research, 2012
In an attempt to understand the basis of glomerular disease, significant progress has been made in understanding the mechanisms that determine podocyte development and the maintenance of podocyte health. This review examines recent advances in this area focusing on the podocyte intercellular junction, actin cytoskeletal dynamics, and determinants of ...
Puneet, Garg, Lawrence B, Holzman
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In an attempt to understand the basis of glomerular disease, significant progress has been made in understanding the mechanisms that determine podocyte development and the maintenance of podocyte health. This review examines recent advances in this area focusing on the podocyte intercellular junction, actin cytoskeletal dynamics, and determinants of ...
Puneet, Garg, Lawrence B, Holzman
openaire +2 more sources
Journal of Cellular Physiology, 2019
Podocyte damage is a hallmark of diabetic nephropathy (DN). Accumulating evidence indicates that microRNAs play important roles in the DN pathogenesis. This study aimed to explore the possible roles and underlying mechanisms of miR‐15b‐5p on high glucose
Yanqin Fu +5 more
semanticscholar +1 more source
Podocyte damage is a hallmark of diabetic nephropathy (DN). Accumulating evidence indicates that microRNAs play important roles in the DN pathogenesis. This study aimed to explore the possible roles and underlying mechanisms of miR‐15b‐5p on high glucose
Yanqin Fu +5 more
semanticscholar +1 more source