Results 291 to 300 of about 64,667 (338)

Role of new podocyte-associated proteins in the renal ultrafiltration barrier

, 2019
Angelina Schwarz
openalex  

Mechanisms of podocyte injury and implications for diabetic nephropathy

Clinical Science, 2022
Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and diabetic nephropathy (DN).
Federica Barutta, Stefania Bellini, Gabriella Gruden   +2 more
exaly   +2 more sources

Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy

Acta Pharmacologica Sinica, 2020
Qian Cheng, Fan Yin, Wei Zhang
exaly   +2 more sources

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Zoning in on podocytes

Kidney International, 2022
Podocytes undergo defined morphologic changes during development, homeostasis, and aging, and on injury. Quantitative podometric assessments of podocyte endowment provide a powerful tool to interrogate glomerular health. Expanding this approach to a regional assessment demonstrates that the podocytes from cortical, subcortical, and juxtamedullary ...
Stuart J, Shankland, Oliver, Wessely
openaire   +2 more sources

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

Nature Communications, 2017
Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance.
Chun Zhang, Chengjiang Gao, Jun Peng
exaly   +2 more sources

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

Nature Communications, 2018
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria.
Lorna J Hale, Sara E Howden, Belinda Phipson   +2 more
exaly   +2 more sources

Cell‐Derived Extracellular Matrix‐Rich Biomimetic Substrate Supports Podocyte Proliferation, Differentiation, and Maintenance of Native Phenotype

Advanced Functional Materials, 2020
Current technologies and available scaffold materials do not support long‐term cell viability, differentiation, and maintenance of podocytes, the ultra‐specialized kidney resident cells that are responsible for the filtration of the blood. A new platform
Abhigyan Satyam, Maria G Tsokos, Di Zeugolis   +2 more
exaly   +2 more sources

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy

Cell Death and Disease, 2019
Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold considerable promise for the treatment of DN.
Ziying Wang, Xiaojie Wang, Yu Sun
exaly   +2 more sources

Podocyte progenitors and ectopic podocytes

Nature Reviews Nephrology, 2013
Two types of parietal podocyte were previously described in the Bowman capsule: one characterized by coexpression of podocyte and parietal epithelial cell markers, the other characterized by expression of podocyte markers only. New research demonstrates that these populations represent podocyte progenitors and ectopic podocytes—distinct cell types with
Laura Lasagni, Paola Romagnani
openaire   +4 more sources

The immune podocyte

Current Opinion in Rheumatology, 2019
Purpose of review Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus and is characterized by proteinuria and renal failure. Proteinuria is a marker of poor prognosis and is attributed to podocyte loss and dysfunction.
Rhea, Bhargava, George C, Tsokos
openaire   +2 more sources