Results 171 to 180 of about 68,048 (352)

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source

Characterization of novel glomerular proteins : role in physiology and disease [PDF]

, 2014
Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy.
Andersson, Ann-Charlotte
core   +1 more source

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Assessment of podocyte detachment as a pivotal step in the development of focal segmental glomerulosclerosis

Journal of the Egyptian National Cancer Institute
Background Podocytopenia refers to a decrease in the number of podocytes. When podocytes are injured, they may detach leading to podocytopenia, which represents a critical step in the development of podocytopathy and subsequently deterioration of renal ...
Ikbal Ahmed Abdo Elkholy, Wagdi Elkashef, Fatma El-Husseini Mostafa, Amany Hassan   +3 more
doaj   +1 more source

Plectin protects podocytes from adriamycin‐induced apoptosis and F‐actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway

Journal of Cellular and Molecular Medicine, 2018
Podocyte injury is an early pathological change characteristic of various glomerular diseases, and apoptosis and F‐actin cytoskeletal disruption are typical features of podocyte injury.
Yongliang Ni, Xin Wang, Xiaoxuan Yin, Yan Li, Xigao Liu, Hai-xin Wang, Xiang Liu, Jun Zhang, Haiqing Gao, B. Shi, Shao-hua Zhao   +10 more
semanticscholar   +1 more source

Fabry Disease Podocytes Reveal Ferroptosis as a Potential Regulator of Cell Pathology

Kidney International Reports
Introduction: Fabry disease (FD) results from pathogenic GLA variants, leading to a deficiency in lysosomal α-galactosidase A (α-Gal A) and accumulation of the sphingolipid globotriaosylceramide (Gb3).
Andrea F. Wise, IGAA Ari Krisnadevi, Shoni Bruell, Han-Chung Lee, Tejasvini Bhuvan, Andrew J. Kassianos, Sheetal Saini, Xiangju Wang, Helen G. Healy, Elizabeth Ling Qian, David A. Elliot, Joel R Steele, Maria Fuller, Kathleen M. Nicholls, Sharon D. Ricardo   +14 more
doaj   +1 more source

Primary Coenzyme Q10 Deficiency [PDF]

, 2017
open4siCLINICAL CHARACTERISTICS: Primary coenzyme Q10 (CoQ10) deficiency is usually associated with multisystem involvement, including neurologic manifestations such as fatal neonatal encephalopathy with hypotonia; a late-onset slowly progressive ...
Doimo, Mara, Navas, P., Salviati, Leonardo, Trevisson, Eva   +3 more
core  

Dynamic changes of podocytes caused by fibroblast growth factor 2 in culture

, 2021
Eishin Yaoita, Masaaki Nameta, Yutaka Yoshida, Hidehiko Fujinaka   +3 more
openalex   +1 more source

Injury-induced actin cytoskeleton reorganization in podocytes revealed by super-resolution microscopy.

JCI Insight, 2017
The architectural integrity of tissues requires complex interactions, both between cells and between cells and the extracellular matrix. Fundamental to cell and tissue homeostasis are the specific mechanical forces conveyed by the actomyosin cytoskeleton.
H. Suleiman, Robyn Roth, Sanjay Jain, J. Heuser, A. Shaw, J. Miner   +5 more
semanticscholar   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, Volume 46, Issue 1, Page 149-175, January 2026.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source