Results 191 to 200 of about 68,048 (352)

Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
The vascular endothelium is highly diverse, regulating permeability, vascular tone, repair, and inter‐organ communication. Endothelial heterogeneity supports tissue‐specific needs, but dysfunction drives cardiovascular disease. Transcriptomics, in vitro models, and redox signaling studies reveal therapeutic targets for precision treatment of ...
Anna E. Williams, Luke S. Dunaway, Zuzanna J. Juśkiewicz, Wyatt J. Schug, Miriam M. Cortese‐Krott, Michael Koval, Brant E. Isakson   +6 more
wiley   +1 more source

A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys [PDF]

, 2019
Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (
Chen, Song, Gao, Derek, Gaut, Joseph, Hoshi, Masato, Jain, Sanjay, Kim, Eric H., Knoten, Amanda, Lake, Blue B., Plongthongkum, Nongluk, Salamon, Diane, Venkatesh, Ramakrishna, Vijayan, Anitha, Zhang, Kun   +12 more
core   +2 more sources

Podocyte injury damages podocytes in chimeric organoids

Abstract We have previously shown that injury to a subset of podocytes can trigger secondary damage in neighboring podocytes, but whether this phenomenon depends on direct intercellular interaction is unknown. To address this, kidney organoids were generated from nephron progenitor cells of two mouse lines: one expressing a receptor for a ...
Tomohiro Udagawa, Toshikazu Araoka, Kenji Osafune, Taiji Matsusaka   +3 more
openaire   +1 more source

Lipid Autophagy: An Idea for the Treatment of Diabetic Nephropathy With Ginseng and Its Active Compounds

eFood, Volume 6, Issue 6, December 2025.
In light of the steadily increasing incidence of diabetic nephropathy (DN), this review explores the potential of edible natural products to slow disease progression, addressing the limitations of conventional clinical drug therapies. Key findings show that ginsenosides, the active compounds in edible ginseng, regulate lipid autophagy, reducing ...
Rui Zhang, Xushan Lan, Chenguang Wu, Jingjing Wang, Chengqian Yin, Lifan Wang, Peng Liu, Ping Li   +7 more
wiley   +1 more source

CKAP4 in Extracellular Vesicle‐Derived From Podocyte Serves as a Non‐Invasive Diagnostic Biomarker for Diabetic Nephropathy and Promotes Vascular Calcification

Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
CKAP4 in uEVs serves as a robust diagnostic indicator for DN and promotes vascular calcification. ABSTRACT Reliable non‐invasive biomarkers for early detection of diabetic nephropathy (DN), a leading cause of chronic kidney disease, remain limited.
Heng Zhang, Kaibin Lou, Li Qian, Min Zhang, Jie Li, Lizhi Lv, Fang Lu, Guiyang He, Chong Wu, Junxiang Wu, Meng Jia, Yang Bai, Shuang Qu, Meng Liu, Laping Chu, Yangtian Wang, Dafa Ding, Ke Zen, Yanggang Yuan, Hongwei Liang   +19 more
wiley   +1 more source

The protective effect and mechanism of catalpol on high glucose-induced podocyte injury [PDF]

, 2019
Yan Chen, Qingpu Liu, Zengfu Shan, Yingying Zhao, Meng Li, Baiyan Wang, Xiaoke Zheng, Weisheng Feng   +7 more
openalex   +1 more source

#6883 PROTECTIVE ROLE OF THE PODOCYTE IL-15 / STAT5 PATHWAY IN EXPERIMENTAL FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS [PDF]

, 2023
Aïssata Niasse, Kévin Louis, Olivia Lenoir, Laurent Mesnard, Juliette Hadchouel, Yosu Luque   +5 more
openalex   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

New Ways of Thinking about Proteinuria and Progression of Renal Damage [PDF]

, 2010
Turner, Neil, Zhou, Y. S.
core   +1 more source

E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

MedComm, Volume 6, Issue 12, December 2025.
E3 ligases function as critical regulators of cellular protein degradation, and their dysregulation is a core pathogenic mechanism in a wide array of human diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and autoimmune diseases.
Haochen Wang, Junbo Peng, Hongchan Li, Yuzhe Lan, Jing Guo, Qiang Qiu, Xuan Huang   +6 more
wiley   +1 more source