Results 91 to 100 of about 13,097 (241)

Prospective validation of podoplanin expression as a diagnostic biomarker of acute promyelocytic leukemia

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Acute promyelocytic leukemia (APL) is a medical emergency that needs immediate diagnosis and treatment. Podoplanin, a transmembrane glycoprotein that binds CLEC‐2 on platelets, was recently demonstrated to be abnormally expressed in leukemic blasts in APL, as opposed to other forms of AML, in a study using thawed primary cells.
Camilla Maria de Alencar Saraiva, Carla Roberta Peachazepi Moraes, Bruno Kosa Lino Duarte, Gislaine Borba Oliveira, Herton Luiz Alves Sales Filho, Paula de Melo Campos, Sara Teresinha Olalla Saad, Erich Vinicius De Paula   +7 more
wiley   +1 more source

Podoplanin: An emerging cancer biomarker and therapeutic target

Cancer Science, 2018
Podoplanin (PDPN) is a transmembrane receptor glycoprotein that is upregulated on transformed cells, cancer associated fibroblasts and inflammatory macrophages that contribute to cancer progression.
Harini Krishnan, Julie Rayes, T. Miyashita, G. Ishii, Edward P. Retzbach, Stephanie A. Sheehan, Ai Takemoto, Yao-Wen Chang, K. Yoneda, J. Asai, L. Jensen, Lushun Chalise, A. Natsume, G. Goldberg   +13 more
semanticscholar   +1 more source

Development of an Anti-Sheep Podoplanin Monoclonal Antibody PMab-256 for Immunohistochemical Analysis of Lymphatic Endothelial Cells

Monoclonal antibodies in immunodiagnosis and immunotherapy, 2020
Sensitive and specific monoclonal antibodies (mAbs) targeting podoplanin (PDPN) are needed for immunohistochemical analyses as a marker for lymphatic endothelial cells.
Y. Kato, Yoshikazu Furusawa, M. Sano, Junko Takei, Takuro Nakamura, Miyuki Yanaka, Saki Okamoto, Saori Handa, Yu Komatsu, Teizo Asano, Yusuke Sayama, M. Kaneko   +11 more
semanticscholar   +1 more source

Biopsy for Suspicious Oral Lesions: A Review From the American Head and Neck Society‐Cancer Prevention Service

Head &Neck, EarlyView.
ABSTRACT Background Oral cancer is often preceded by a precursor lesion. This presents an opportunity for early diagnosis and intervention. Method of biopsy and interpretation are not well standardized and novel methods of analysis are now being investigated.
James Christopher Gates, Heather Edwards, Alessandro Villa, Nick Purdy, Michael Troka, Peter Varela, Quinn Self, Yingci Liu, Yusuf Dundar, Patricia Joyce Brooks, Dauren Adilbay, Andrew Birkeland, John Cramer   +12 more
wiley   +1 more source

Podoplanin is a negative regulator of Th17 inflammation [PDF]

JCI Insight, 2017
Recent data indicate that there are different subpopulations of Th17 cells that can express a regulatory as opposed to an inflammatory gene signature. The transmembrane glycoprotein PDPN is critical in the development of multiple organs including the lymphatic system and has been described on T cells in mouse models of autoimmune Th17 inflammation ...
Alyssa N, Nylander, Gerald D, Ponath, Pierre-Paul, Axisa, Mayyan, Mubarak, Mary, Tomayko, Vijay K, Kuchroo, David, Pitt, David A, Hafler   +7 more
openaire   +2 more sources

Expression of podoplanin in oral premalignant and malignant lesions and its potential as a biomarker

Indian Journal of Dental Research, 2014
Aim: To analyze and compare the expression of podoplanin in normal oral tissues, leukoplakia and oral squamous cell carcinoma (OSCC) and to predict its use as a biomarker. Materials and Methods: Ninety-two formalin fixed paraffin embedded tissue samples
J Logeswari, N Malathi, H Thamizhchelvan, N Sangeetha, S Vijaya Nirmala   +4 more
doaj   +1 more source

Keratinocyte-Expressed Podoplanin is Dispensable for Multi-Step Skin Carcinogenesis

Cells, 2020
Podoplanin is a small transmembrane mucin-like glycoprotein that plays a crucial role in the development of the lung, heart and lymphatic vascular system.
Marko Sesartić, Kristian Ikenberg, Sun-Young Yoon, Michael Detmar   +3 more
doaj   +1 more source

Podoplanin—a novel marker in oral carcinogenesis

Tumor Biology, 2014
Podoplanin, a transmembrane sialoglycoprotein, is a specific marker for lymphatic endothelial cells which in recent years has gained prominent notoriety for its role in tumor progression and metastasis. It is an extensively studied biomarker for predictive assessment of malignant transformation as well as biologic behavior in both human precancer and ...
Niharika, Swain, Shwetha V, Kumar, Samapika, Routray, Jigna, Pathak, Shilpa, Patel   +4 more
openaire   +2 more sources

Src Induces Podoplanin Expression to Promote Cell Migration [PDF]

Journal of Biological Chemistry, 2010
Nontransformed cells can force tumor cells to assume a normal morphology and phenotype by the process of contact normalization. Transformed cells must escape this process to become invasive and malignant. However, mechanisms underlying contact normalization have not been elucidated.
Shen, Yongquan, Chen, Chen-Shan, Ichikawa, Hitoshi, Goldberg, Gary   +3 more
openaire   +3 more sources

Cancer‐Specific Antihuman Podoplanin Antibody chLpMab‐2f Exerts Antitumor Effects Against Pleural Mesothelioma

Cancer Science, EarlyView.
Cancer‐specific antihuman podoplanin antibody chLpMab‐2f exerted antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against pleural mesothelioma (PM) cell lines. Additionally, chLpMab‐2f inhibited tumor progression in mice with subcutaneously and intrathoracically transplanted human PM cells.
Aito Yoshida, Shinji Abe, Toshihiro Izumi, Satoshi Itakura, Keichiro Yamada, Takuya Wada, Takaaki Yamamoto, Chiemi Sato, Atsushi Mitsuhashi, Hirokazu Ogino, Seidai Sato, Tsutomu Shinohara, Masaki Hanibuchi, Mika K. Kaneko, Yukinari Kato, Yasuhiko Nishioka   +15 more
wiley   +1 more source