Results 101 to 110 of about 19,338 (290)

Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas [PDF]

, 2011
Background: Podoplanin expression is attracting interest as a marker for cancer diagnosis and prognosis. We therefore investigated the expression pattern and clinical significance of podoplanin during the development and progression of laryngeal ...
Fresno, M.F. (Manuel), García-Carracedo, Darío, García-Pedrero, Juana, González, M.V. (María), Mancebo, Gonzalo, Rodrigo, J.P. (Juan)   +5 more
core  

Podoplanin, a Potential Therapeutic Target for Nasopharyngeal Carcinoma [PDF]

BioMed Research International, 2019
Introduction. The role of podoplanin (PDPN) in nasopharyngeal carcinoma (NPC) is still unknown. The aims of this study were to investigate the expression and role of PDPN in NPC cells.Materials and Methods. Immunofluorescence staining and functional tests were used to determine the effects of PDPN knockdown by siRNA in TW01 NPC cells.
Kuan-Ting Lin, Ming-Chin Lan, Ming Ying Lan, Ming Ying Lan, Yen Bin Hsu, Yen Bin Hsu, Yu-Lun Kuo, Chi Ying F. Huang   +7 more
openaire   +3 more sources

Reduced Mitochondrial Adenine Nucleotide Translocase 1 (ANT1) Correlates With Aging‐Associated Airway Remodeling

Aging Cell, EarlyView.
Adenine nucleotide translocase 1 (ANT1), a mitochondrial ATP transporter, is decreased in the lung epithelium of aged adults and aged mice correlating to pathogenic airway changes. Loss of ANT1 correlates with increased cellular senescence and changes in COL8A1 in the airway epithelium of the lung.
Roshani Jha, Jian Shi, Maggie J. Sedgwick, Justin Sui, Timothy E. Corcoran, Corrine R. Kliment   +5 more
wiley   +1 more source

Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2

Retrovirology, 2010
Background Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream.
Münch Jan, Schmökel Jan, Kato Yukinari, Glowacka Ilona, Bertram Stephanie, Tsegaye Theodros, Steffen Imke, Chaipan Chawaree, Simmons Graham, Gerardy-Schahn Rita, Pöhlmann Stefan   +10 more
doaj   +1 more source

Mononuclear Phagocyte System Depletion Blocks Interstitial Tonicity-Responsive Enhancer Binding Protein/Vascular Endothelial Growth Factor C Expression and Induces Salt-Sensitive Hypertension in Rats [PDF]

, 2010
We showed recently that mononuclear phagocyte system (MPS) cells provide a buffering mechanism for salt-sensitive hypertension by driving interstitial lymphangiogenesis, modulating interstitial Na(+) clearance, and increasing endothelial NO synthase ...
Dahlmann, A., Eckardt, K.U., Goss, J., Kerjaschki, D., Kopp, C., Luft, F.C., Machnik, A., Muller, D.N., Park, J.K., Rooijen, N. van, Titze, J., Wagner, H.   +11 more
core   +2 more sources

Design and Evaluation of Eb4Mab‐7‐mG2a: A Dual‐Action Anti‐EphB4 Monoclonal Antibody for Targeted Breast Cancer Therapy

Cancer Science, EarlyView.
Eb4Mab‐7‐mG2a, an anti‐EphB4 monoclonal antibody, significantly suppressed tumor growth in the MCF‐7 xenograft model. Tumor volume and weight were markedly reduced in treated mice, demonstrating its antitumor efficacy against EphB4‐positive breast cancer.
Tomokazu Ohishi, Hiroyuki Suzuki, Mika K. Kaneko, Tomohiro Tanaka, Akiko Harakawa, Junjiro Yoshida, Daisuke Tatsuda, Yukinari Kato, Manabu Kawada   +8 more
wiley   +1 more source

Study of Podoplanin Expression in Head and Neck Squamous Cell Carcinoma

Iranian Journal of Pathology, 2021
Background & Objective: Head and Neck Squamous cell carcinoma (HNSCC) is one of the leading cancers worldwide. Cervical lymph node metastasis is the most adverse prognostic factor for patients with HNSCC.
Anjali Mary Jibi, V. Basavaraj
semanticscholar   +1 more source

A patient‐derived orthotopic xenograft model unveils metastatic dynamics in head and neck squamous cell carcinoma

The FEBS Journal, EarlyView.
Metastasis in head and neck squamous cell carcinoma (HNSC) poses significant clinical challenges. This proof‐of‐concept study establishes patient‐derived orthotopic xenografts (PDOXs) as advanced models that closely replicate primary HNSC tumours, including local lymph node metastasis and the intricate cancer–stroma interaction.
Yuchen Bai, Benjamin Blyth, Jarryd Boath, Qiji Deng, Ruihong Huang, Charbel Darido   +5 more
wiley   +1 more source

Association of the co-expression of SOX2 and Podoplanin in the progression of oral squamous cell carcinomas - an immunohistochemical study

Journal of Applied Oral Science
SOX2 is a transcription factor related to the maintenance of stem cells in a pluripotent state. Podoplanin is a type of transmembrane sialoglycoprotein, which plays an important role in tumor progression and metastasis.
Sonali Pradhan, Vasudeva Guddattu, Monica Charlotte Solomon   +2 more
doaj   +1 more source

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis

Platelets, 2018
The podoplanin-CLEC-2 axis is critical in mice for prevention of hemorrhage in the cerebral vasculature during mid-gestation. This raises the question as to how platelets are captured by podoplanin on neuroepithelial cells in a high shear environment. In
Stephanie E. Lombard, Alice Y. Pollitt, Craig E. Hughes, Ying Di, Tom Mckinnon, Chris A. O’callaghan, Steve P. Watson   +6 more
doaj   +1 more source