Results 41 to 50 of about 504,749 (254)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

PERFIL PSICOLÓGICO DE LOS ESTUDIANTES DE 1er AÑO DE ENFERMERÍA: ESTUDIO PRELIMINAR

Ciencia y Enfermería
La presente investigación tuvo como propósito elaborar un perfil de los estudiantes de primer año de la carrera de Enfermería de la Universidad Santo Tomás, con la finalidad de obtener información sobre los diversos ámbitos del funcionamiento del alumno.
Matías Ríos Erazo, Laura Moncada Arroyo, Gabriela Llanos Román, Rosario Santana González, Herminia Salinas Gálvez   +4 more
doaj   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Congruences of lines in $\mathbb{P}^5$, quadratic normality, and completely exceptional Monge-Amp\`ere equations

, 2007
The existence is proved of two new families of locally Cohen-Macaulay sextic threefolds in $\mathbb{P}^5$, which are not quadratically normal. These threefolds arise naturally in the realm of first order congruences of lines as focal loci and in the ...
E. Mezzetti, E. Mezzetti, E. Mezzetti, Emilia Mezzetti, G. Boillat, G. Ottaviani, L. Chiantini, L. Gruson, L. Koelblen, L. Manivel, M. Roggero, M.C. Chang, M.L. Fania, M.L. Fania, P. Poi De, P. Poi De, Pietro De Poi, S.I. Agafonov, S.J. Kwak   +18 more
core   +1 more source

Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China

Advanced Science, EarlyView.
This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang, Yadong Yang, Yongsheng Wang, Guirui Yu   +3 more
wiley   +1 more source

Risk factors and outcomes associated with postoperative ileus following ileostomy formation: a retrospective study

Perioperative Medicine, 2021
Background Postoperative ileus (POI) is associated with increased patient discomfort, length of stay (LOS), and healthcare cost. There is a paucity of literature examining POI in patients who have an ileostomy formed at the time of surgery.
Anya L. Greenberg, Yvonne M. Kelly, Rachel E. McKay, Madhulika G. Varma, Ankit Sarin   +4 more
doaj   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

A Machine Learning-Based Classification System for Urban Built-Up Areas Using Multiple Classifiers and Data Sources

Remote Sensing, 2019
Information about urban built-up areas is important for urban planning and management. However, obtaining accurate information about urban built-up areas is a challenge.
Lang Sun, Lina Tang, Guofan Shao, Quanyi Qiu, Ting Lan, Jinyuan Shao   +5 more
doaj   +1 more source

The Flexible Group Spatial Keyword Query

, 2017
We present a new class of service for location based social networks, called the Flexible Group Spatial Keyword Query, which enables a group of users to collectively find a point of interest (POI) that optimizes an aggregate cost function combining both ...
D Papadias, G Cong, GR Hjaltason, K Yao, ME Ali, N Roussopoulos, X Cao, Z Li   +7 more
core   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source