Results 51 to 60 of about 504,749 (254)

Biallelic Germline Inactivation of HROB Causes Primary Gonadal Insufficiency and is Potentially Associated with Colonic Polyposis Predisposition

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The Homologous Recombination Factor With OB‐Fold (HROB) plays a role in homologous recombination and DNA replication, where it enhances the MCM8‐MCM9 helicase complex activity. Recent findings link biallelic germline HROB variants to primary gonadal insufficiency (hypergonadotropic hypogonadism), a phenotype also associated with MCM8/MCM9 ...
Noah C. Helderman, Carli M. Tops, Jelmer Legebeke, Ting Yang, Marcos Díaz Gay, Diantha Terlouw, Lisa E. E. L. O. Lashley, Stefan Aretz, Anna K. Sommer, Mariona Terradas, Laura Valle, Richarda M. de Voer, Ludmil B. Alexandrov, Hans Morreau, Tom van Wezel, Maartje Nielsen   +15 more
wiley   +1 more source

BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS

EMBO Molecular Medicine, 2023
Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle‐stimulating hormone. Though POI affects many aspects of women's health, its major causes remain unknown.
Xiao Guo, Yuemeng Zhu, Lu Guo, Yiwen Qi, Xiaocheng Liu, Jinhui Wang, Jiangtao Zhang, Linlin Cui, Yueyang Shi, Qichu Wang, Cenxi Liu, Guangxing Lu, Yilian Liu, Tao Li, Shangyu Hong, Yingying Qin, Xuelian Xiong, Hao Wu, Lin Huang, He Huang, Chao Gu, Bin Li, Jin Li   +22 more
doaj   +1 more source

Gaussian Processes for Predictive QSAR Modeling of Chromatographic Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chromatography is a key unit operation in the biopharmaceutical manufacturing process used for protein purification and polishing. Design and optimization of these processes are resource‐intensive resulting from the complex combinatorial design space.
Harini Narayanan, Douglas Nolan, Lijuan Li, Edward King, Andrew Fiordalis, David Benjamin Nickel, George Parks, J. Christopher Love   +7 more
wiley   +1 more source

Learning Points and Routes to Recommend Trajectories

, 2016
The problem of recommending tours to travellers is an important and broadly studied area. Suggested solutions include various approaches of points-of-interest (POI) recommendation and route planning.
Cheng C., Lim K. H., Liu Q., Papadimitriou C. H., Shi Y., Sinnott R. W.   +5 more
core   +1 more source

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction

Biotechnology and Bioengineering, EarlyView.
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang, Keilung Choy, Eli Reiser, Jinxiang Pei, Hua Zheng, Aparajita Dasgupta, Fuqiang Cheng, Guogang Dong, Bhanu Chandra Mulukutla, Joshua Mannheimer, Carolyn Huang, Hooman Farsani, Wei Xie   +12 more
wiley   +1 more source

Impact of Natural Fermentation on Mineral Composition, Resistant and Non-Resistant Starches, Microbial Diversity, and Global Metabolite Profiles in Commercial Poi from Hawai‘i

Metabolites
Background/Objectives: Taro (Colocasia esculenta L.) is a nutritionally rich and historically significant crop widely consumed in tropical and subtropical regions.
Nyan Stillwell, Vedbar S. Khadka, Pratibha V. Nerurkar   +2 more
doaj   +1 more source

MicroRNA-4516 in Urinary Exosomes as a Biomarker of Premature Ovarian Insufficiency

Cells, 2022
Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea that lasts for a minimum of four months in women < 40 years old and is typically characterized by reduced estrogen levels and elevated serum concentrations of follicle-stimulating ...
Zobia Umair, Mi-Ock Baek, Jisue Song, Seona An, Seung Joo Chon, Mee-Sup Yoon   +5 more
doaj   +1 more source

Operation Immunization – APhA Academy of Student Pharmacists [PDF]

, 2013
IMPACT. 1: Pharmacists can immunize in 50 states. We can serve as vaccine advocates or facilitators by creating partnerships with other health care professionals to have immunizations administered in a pharmacy. -- 2. Most student pharmacists are trained
Poi, Ee Jye
core  

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Discovery and characterization of submarine groundwater discharge in the Siberian Arctic seas: a case study in the Buor-Khaya Gulf, Laptev Sea [PDF]

The Cryosphere, 2017
It has been suggested that increasing terrestrial water discharge to the Arctic Ocean may partly occur as submarine groundwater discharge (SGD), yet there are no direct observations of this phenomenon in the Arctic shelf seas.
A. N. Charkin, A. N. Charkin, M. Rutgers van der Loeff, N. E. Shakhova, N. E. Shakhova, Ö. Gustafsson, O. V. Dudarev, O. V. Dudarev, M. S. Cherepnev, A. N. Salyuk, A. V. Koshurnikov, E. A. Spivak, A. Y. Gunar, A. S. Ruban, I. P. Semiletov, I. P. Semiletov, I. P. Semiletov   +16 more
doaj   +1 more source