Results 51 to 60 of about 117,345 (255)
Constant Distortion Embeddings of Symmetric Diversities
Analysis and Geometry in Metric Spaces, 2016 Diversities are like metric spaces, except that every finite subset, instead of just every pair of points, is assigned a value. Just as there is a theory of minimal distortion embeddings of fiite metric spaces into L1, there is a similar, yet undeveloped,
Bryant David, Tupper Paul F.
doaj +1 more source
A Method Based on Temporal Embedding for the Pairwise Alignment of Dynamic Networks
Entropy, 2023 In network analysis, real-world systems may be represented via graph models, where nodes and edges represent the set of biological objects (e.g., genes, proteins, molecules) and their interactions, respectively.
Pietro Cinaglia, Mario Cannataro
doaj +1 more source
Upward straight-line embeddings of directed graphs into point sets
Computational Geometry, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Carla Binucci +6 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
JMIR Medical Informatics, 2022 BackgroundTriage of textual telemedical queries is a safety-critical task for medical service providers with limited remote health resources.
Joseph Gatto +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Families of Smooth Rational Curves of Small Degree on the Fano Variety of Degree 5 of Main Series
Моделирование и анализ информационных систем, 2013 In this paper we consider some families of smooth rational curves of degree 2, 3 and 4 on a smooth Fano threefold X which is a linear section of the Grassmanian G(1, 4) under the Pl¨ucker embedding. We prove that these families are irreducible. The proof
M. S. Omelkova
doaj +3 more sources