Results 91 to 100 of about 146,403 (298)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
, 2016 The family of all subcontinua that separate a compact connected $n$-manifold $X$ (with or without boundary), $n\ge 3$, is an $F_\sigma$-absorber in the hyperspace $C(X)$ of nonempty subcontinua of $X$.
Krupski, Paweł, Samulewicz, Alicja
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Solar energy collection system [PDF]
, 1979 A fixed, linear, ground-based primary reflector having an extended curved sawtooth-contoured surface covered with a metalized polymeric reflecting material, reflects solar energy to a movably supported collector that is kept at the concentrated line ...
Miller, C. G., Stephens, J. B.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Energies, 2019 The research presented in this paper investigates novel ways of optimizing all-electric wave energy converters for maximum wave-to-wire efficiency. In addition, a novel velocity-based controller is presented which was designed specifically for wave-to ...
Marios Charilaos Sousounis +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Stochastic Rating of Storage Systems in Isolated Networks with Increasing Wave Energy Penetration
Energies, 2013 The future success of wave energy in the renewable energy mix depends on the technical advancements of the specific components and systems, on the grid access availability and, ultimately, on the economical profitability of the investment.
Elisabetta Tedeschi +3 more
doaj +1 more source
Supermodes of high-repetition-rate passively mode-locked semiconductor lasers [PDF]
, 1996 We present a steady-state analysis of high-repetition-rate passively mode-locked semiconductor lasers. The analysis includes effects of amplitude-to-phase coupling in both gain and absorber sections. A many-mode eigenvalue approach is presented to obtain
Salvatore, Randal A. +3 more
core
Cross correlation of Lyman-alpha absorbers with gas-rich galaxies
, 2006 The HI Parkes All Sky Survey (HIPASS) galaxy catalogue is cross-correlated with known low redshift, low column density (N_HI
Ryan-Weber, Emma V.
core +1 more source