Results 71 to 80 of about 4,571,541 (292)

Geometric Development of Point Absorber Wave Energy Conventer

MATEC Web of Conferences, 2018
This paper describes how to design the shape of a floating object that will be used as a point absorber on wave energy converster. The buoyant shape to be analyzed is a tube has a flat top plane with varying bottom plane, i.e cylinder, hemisphare and ...
Saptono Warpindyasmoro Heri, Gunadi Kartika   +1 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

RANS-VOF modelling of the Wavestar point absorber [PDF]

Renewable Energy, 2017
Highlights•A fully nonlinear, coupled model of the Wavestar WEC has been created using open-source CFD software, OpenFOAM®.•The response of the Wavestar WEC is simulated in regular waves with different steepness.•Predictions of body motion, surface elevation, fluid velocity, pressure and load are compared with physical measurements.•Model stability is ...
E.J. Ransley, D.M. Greaves, A. Raby, D. Simmonds, M.M. Jakobsen, M. Kramer   +5 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Economic Shocks and Exchange Rate as a Shock Absorber in Indonesia and Thailand [PDF]

This study investigates the requirement for the exchange rate to be a shock absorber in Indonesia and Thailand from 1986 to 2007. In general, we find that the economic shocks have predominantly been asymmetric relative to the US and the Japanese ...
Siregar, Reza Y. Siregar, Goo, Siwei
core   +2 more sources

SWAN–WEC: Introducing an Innovative Design for a Deep Water Point Absorber Wave Energy Converter

Journal of Marine Science and Engineering
Meeting the growing demand for renewable energy production requires tapping into a variety of natural resources. Wave energy, while abundant, remains a challenging and often non-economic field.
Daniel Bar, Nitai Drimer
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Central Point Notice of Adopted Amendment (2012-06-04) [PDF]

, 2012
46 pp. Adopted 2012-06-04. Department of Land Conservation and Development Notice of Adopted AmendmentComprehensive Plan Map (Exhibit 1) and concurrent Zone Map (Exhibit 2 change for 7.61 acres within the UGE of Central Point from Neighborhood ...
Myrtle Point (Or.), Central Point (Or.)
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source