Results 71 to 80 of about 147,233 (294)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Photometric and Spectral Signatures of 3D Models of Transiting Giant Exoplanets
, 2010 Using a 3D GCM, we create dynamical model atmospheres of a representative transiting giant exoplanet, HD 209458b. We post-process these atmospheres with an opacity code to obtain transit radius spectra during the primary transit.
Burrows, Adam +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A Design Outline for Floating Point Absorber Wave Energy Converters
Advances in Mechanical Engineering, 2014 An overview of the most important development stages of floating point absorber wave energy converters is presented. At a given location, the wave energy resource has to be first assessed for varying seasons. The mechanisms used to convert wave energy to
Mohammed Faizal +2 more
doaj +1 more source
Theoretical Spectral Models of the Planet HD 209458b with a Thermal Inversion and Water Emission Bands [PDF]
, 2007 We find that a theoretical fit to all the HD 209458b data at secondary eclipse requires that the dayside atmosphere of HD 209458b have a thermal inversion and a stratosphere.
A. Burrows +5 more
core +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Marine Science and Engineering, 2020 Mathematical models are essential for the design and control of offshore systems, to simulate the fluid–structure interactions and predict the motions and the structural loads.
Giuseppe Giorgi +5 more
doaj +1 more source
Low cost solar energy collection system [PDF]
, 1977 A fixed, linear, ground-based primary reflector having an extended, curved sawtooth contoured surface covered with a metallized polymeric reflecting material, reflected solar energy to a movably supported collector that was kept at the concentrated line ...
Miller, C. G., Stephans, J. B.
core +1 more source
Simulations of a Scintillator Compton Gamma Imager for Safety and Security
, 2009 We are designing an all-scintillator Compton gamma imager for use in security investigations and remediation actions involving radioactive threat material.
Hanna, D. S. +3 more
core +1 more source