Results 111 to 120 of about 5,624,947 (339)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Energies, 2018 A wave-energy converter has been studied through the combination of laboratory experiments and numerical simulations. The converter model is a semi-submerged axi-symmetric buoy with a circular cross section with a diameter of 26 cm at the water plane ...
Amélie Têtu +3 more
doaj +1 more source
An extended multi-zone model for the MCG-6-30-15 warm absorber
, 2000 The variable warm absorber seen with {\em ASCA} in the X-ray spectrum of MCG$-$6-30-15 shows complex time behaviour in which the optical depth of OVIII anticorrelates with the flux whereas that of OVII is unchanging.
Fabian, A. C. +2 more
core +4 more sources
Buoy Analysis in a Point-Absorber Wave Energy Converter
IEEE Journal of Oceanic Engineering, 2020 In this paper, a single-body point absorber system is analyzed to enhance its power absorption performance. The wave energy converter consists of a single floating body coupled to a direct-drive power takeoff system placed on the seabed.
Aldo Ruezga, José M. Cañedo C.
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Journal of Marine Science and EngineeringIntegrating wave energy converters (WECs) onto floating offshore wind turbine platforms has emerged as a recent focal point of research aiming to achieve synergistic marine energy utilization and enhance the spatial efficiency of renewable energy.
Mingsheng Chen +7 more
doaj +1 more source
Energies, 2018 In this paper, a shape optimization method of a truncated conical point absorber wave energy converter is proposed. This method converts the wave energy absorption efficiency into the matching problem between the wave spectrum of the South China Sea and ...
Yadong Wen +6 more
doaj +1 more source
Reliability‐based hull geometry optimisation of a point‐absorber wave energy converter with power take‐off structural reliability objectives [PDF]
, 2021 Anna Garcia‐Teruel, Caitlyn Clark
openalex +1 more source
, 2020 In this paper, we compare the heave, surge, and pitch dynamics of a submerged cylindrical point absorber, simulated using potential flow and fully resolved computational fluid dynamics (CFD) models.
Panagiotis Dafnakis +5 more
semanticscholar +1 more source