Results 91 to 100 of about 2,950,804 (330)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Noncooperative Spacecraft Pose Estimation Based on Point Cloud and Optical Image Feature Collaboration

Aerospace
Pose estimation plays a crucial role in on-orbit servicing technologies. Currently, point cloud registration-based pose estimation methods for noncooperative spacecraft still face the issue of misalignment due to similar point cloud structural features ...
Qianhao Ning, Hongyuan Wang, Zhiqiang Yan, Zijian Wang, Yinxi Lu   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Computer Model for an Intelligent Adjustment of Weather Conditions Based on Spatial Features for Soil Moisture Estimation

Mathematics
In this paper, an intelligent weather conditions fuzzy adjustment based on spatial features (IWeCASF) is developed. It is indispensable for our regional soil moisture estimation approach, complementing a point estimation model of soil moisture from the ...
Luis Pastor Sánchez-Fernández, Diego Alberto Flores-Carrillo, Luis Alejandro Sánchez-Pérez   +2 more
doaj   +1 more source

Point estimation for adaptive trial designs I: A methodological review. [PDF]

Stat Med, 2023
Robertson DS, Choodari-Oskooei B, Dimairo M, Flight L, Pallmann P, Jaki T.   +5 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Point Estimation [PDF]

, 2020
  +4 more sources

Point estimation for adaptive trial designs II: Practical considerations and guidance. [PDF]

Stat Med, 2023
Robertson DS, Choodari-Oskooei B, Dimairo M, Flight L, Pallmann P, Jaki T.   +5 more
europepmc   +1 more source

A Composite Likelihood-based Approach for Change-point Detection in Spatio-temporal Process

, 2019
This paper develops a unified, accurate and computationally efficient method for change-point inference in non-stationary spatio-temporal processes. By modeling a non-stationary spatio-temporal process as a piecewise stationary spatio-temporal process ...
Ma, Ting Fung, Ng, Wai Leong, Yau, Chun Yip, Zhao, Zifeng   +3 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source