Results 121 to 130 of about 2,950,804 (330)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Launching Point Estimation Using Inverse First-Order Pitch Programming

open access: yesMathematics
This paper presents an estimation of the launching points of unmanned aerial vehicles (UAVs) equipped with boosters. When UAVs are detected and tracked by sensors such as radars, the fast identification of vehicle launching points is needed for air ...
Sungjin Cho   +2 more
doaj   +1 more source

Density Unbiased Point Estimates

open access: yesThe Annals of Mathematical Statistics, 1954
A new concept of unbiasedness (density unbiasedness) for point estimates is introduced and the "best" density unbiased point estimate for the mean of any normal distribution is proved to be the ordinary sample mean $\bar{x} = \sum^n_{i = 1} x_i/n$. Under certain conditions on the form of the characteristic function of a family of probability density ...
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Pose estimation algorithm based on point pair features using PointNet +  + 

open access: yesComplex & Intelligent Systems
This study proposes an innovative deep learning algorithm for pose estimation based on point clouds, aimed at addressing the challenges of pose estimation for objects affected by the environment.
Yifan Chen   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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