Results 51 to 60 of about 283,852 (314)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Joint Geometry and Attribute Upsampling of Point Clouds Using Frequency-Selective Models with Overlapped Support [PDF]

, 2023
Viktoria Heimann, Andreas Spruck, André Kaup   +2 more
openalex   +1 more source

Absolute Embeddings of Point–Line Geometries

Journal of Algebra, 2001
The paper concerns the existence of absolute embeddings \(e\) of point-line geometries \(\Gamma=({\mathcal P},{\mathcal L})\), that is, any embedding of \(\Gamma\) in some projective space can be derived from \(e\) by projecting onto suitable quotient spaces.
Kasikova, A, Shult, E
openaire   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Autoencoder Architectures for Low-Rate Sparse Point Cloud Geometry Coding

IEEE Access
Efficient compression of sparse point cloud geometry remains a critical challenge in 3D content processing, particularly for low-rate scenarios where conventional codecs struggle to maintain efficiency. This work proposes a system-level framework for low-
Ivaylo Bozhilov, Radostina Petkova, Krasimir Tonchev, Agata Manolova, Vladimir Poulkov, H. Vincent Poor   +5 more
doaj   +1 more source

EXPERIMENTS WITH UAS IMAGERY FOR AUTOMATIC MODELING OF POWER LINE 3D GEOMETRY [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015
The ideal mapping technology for transmission line inspection is the airborne LiDAR executed from helicopter platforms. It allows for full 3D geometry extraction in highly automated manner.
G. Jóźków, B. Vander Jagt, C. Toth
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

GPV-Pose: Category-level Object Pose Estimation via Geometry-guided Point-wise Voting [PDF]

, 2022
Di Yan, Ruida Zhang, Zhiqiang Lou, Fabian Manhardt, Xiangyang Ji, Nassir Navab, Federico Tombari   +6 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source