Results 51 to 60 of about 196,393 (286)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Advances in Civil Engineering, 2023 In order to evaluate the shear strength and behavior of high-strength concrete beams without web reinforcing, eight high-strength continuous concrete beams with cross sections of 200 mm by 300 mm were cast and tested to failure.
Bamo Ahmed Hasan, Jalal Ahmed Saeed
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Point load strength of granodiorites from the Plana pluton
Engineering Geology and Hydrogeology, 2018 The studied area is located in the southeast parts of the Plana Mountain. It is built up of Plana diorite pluton, represented by granodiorites, quartz-diorites and quartz-monzonites, which is located among the older (Precambrian) metamorphic rocks (gneisses, amphibolites, schists and fillites).
Plamen Ivanov +2 more
openaire +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Numerical Investigations of Small Punch Tests for Determining Tensile Properties
Ubiquity Proceedings, 2018 Small punch tests were conducted for carbon steel specimens prepared with and without cold working. A digital image correlation technique was applied to measure displacement.
M. Kamaya
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Understanding and overcoming the sticking point in resistance exercise
, 2016 In the context of resistance training the so-called ‘‘sticking point’’ is commonly understood as the 9 position in a lift in which a disproportionately large increase in the difficulty to continue the lift is experienced.
Kompf, Justin +3 more
core +1 more source