Results 71 to 80 of about 187,835 (253)

Punching strength of RC slabs with asymmetric point loads

, 2016
تعرض هذه الورقة نتائج الاختبارات على 18 بلاطة خرسانية مسلحة أحادية الاتجاه تحت أحمال نقطية لها متغير رئيسي هو نسبة التعزيز العرضي للثني وموضع التحميل وعرض البلاطة. يتم وصف استجابة الألواح ومناقشتها من حيث الانحرافات وسلالات الخرسانة وقضبان التسليح ونمط التكسير وأنماط الفشل وأحمال الفشل.
Maurício de Pina Ferreira, Paulo Sacramento, A. F. Lima Neto, Marcelo Teixeira, Dênio Ramam Carvalho de Oliveira   +4 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Estimation of uniaxial compressive strength from point load strength,

, 2008
Uniaxial compressive strength is considered one of the most important parameters in the characterization of rock material in rock engineering practice. The study investigated correlations between uniaxial compressive strength and point load index, P-wave velocity and Schmidt hardness rebound number together with the effects of core diameter size.
Cobanoglu, I, Celik, SB
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Experimental Study on the Flexural Performance of Geogrid-Reinforced Foamed Lightweight Soil

Buildings
The flexural behavior of geogrid-reinforced foamed lightweight soil (GRFL soil) is investigated in this study using unconfined compressive and four-point bending tests.
Yinhe Li, Yong Liu, Hongbo Zhang, Ning An, Zuolin Fan   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Correlation Between P-wave Velocity and Strength Index for Shale to Predict Uniaxial Compressive Strength Value

MATEC Web of Conferences, 2017
Seismic refraction survey is a non destructive method used in site investigation to identify the seismic velocity subsurface strata. Although it is widely known, the reliability of the result is still doubtable for some reason as well as due to an ...
Awang H., Ahmad Rashidi N. R., Yusof M., Mohammad K.   +3 more
doaj   +1 more source

Point defect effects on tensile strength of α−zirconium studied by molecular dynamics simulations

Nuclear Materials and Energy, 2019
Vacancy, interstitial, and Frenkel pair effects on the tensile strength of α−Zr are studied by molecular dynamics simulations. The uni-axial tensile load is along [0001] direction of the α−Zr samples.
Yingying Li, Hong Chen, Yuting Chen, Yuhua Wang, Liang Shao, Wei Xiao   +5 more
doaj   +1 more source