Results 131 to 140 of about 6,585,062 (339)

A point mutation in the tobacco mosaic virus capsid protein gene induces hypersensitivity in Nicotiana sylvestris [PDF]

, 1988
David A. Knorr, William O. Dawson
openalex   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

THE EFFECTS OF DELETIONS, POINT MUTATIONS, REVERSIONS AND SUPPRESSOR MUTATIONS ON THE TWO COMPONENTS OF THE TRYPTOPHAN SYNTHETASE OF ESCHERICHIA COLI

, 1959
Charles Yanofsky, Irving P. Crawford
openalex   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

THE FINE STRUCTURE OF THE LOCI tryC AND tryD OF SALMONELLA TYPHIMURIUM. I. DETERMINATION OF THE ORDER OF MUTATIONAL SITES BY THREE-POINT TRANSDUCTION TESTS

, 1962
Elias Balbinder
openalex   +2 more sources

Induction of recessive lethal mutations in theT/t–H-2region of the mouse genome by a point mutagen [PDF]

, 1986
Alexandra Shedlovsky, Jean‐Louis Guénet, Lawrence L. Johnson, William F. Dove   +3 more
openalex   +1 more source

Repeat-Induced Point Mutation and Other Genome Defense Mechanisms in Fungi

Microbiology spectrum, 2017
Eugene Gladyshev
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Adenovirus 5 early region 1A host range mutants hr3, hr4, and hr5 contain point mutations which generate single amino acid substitutions [PDF]

, 1985
Gary Glenn, Robert P. Ricciardi
openalex   +1 more source

Point Mutations of P2X7 Receptors [PDF]

Biophysical Journal, 2020
Fritz Markwardt, Guenther Schmalzing, Manuela Klapperstück, Hannah Dentler   +3 more
openaire   +2 more sources