Results 151 to 160 of about 6,585,062 (339)
Site-directed point mutation in the src gene oF rous sarcoma virus results in an inactive src gene product [PDF]
, 1983 D Bryant, J. Thomas Parsons
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
CROSSES BETWEEN INSERTION AND POINT MUTATIONS IN Λ GENE cI: STIMULATION OF NEIGHBORING RECOMBINATION BY HETEROLOGY [PDF]
, 1984 Margaret Lieb +2 more
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
27 STRUCTURAL CONSEQUENCES OF POINT MUTATIONS IN NINE HUMAN HPRT VARIANTS [PDF]
, 1988 Beverly L. Davidson +3 more
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Point mutation impairs centromeric CENH3 loading and induces haploid plants
Proceedings of the National Academy of Sciences of the United States of America, 2015 Raheleh Karimi-Ashtiyani +14 more
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A point mutation of low‐density‐lipoprotein receptor causing rapid degradation of the receptor [PDF]
, 1992 Yasuko Miyake +4 more
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