Results 151 to 160 of about 1,268,660 (340)

Modified pea apyrase has altered nuclear functions and enhances the growth of yeast and Arabidopsis

Frontiers in Plant Science
Apyrases (NTPDases) regulate growth and development in multiple eukaryotic organisms and function in multiple sub-cellular locales. An earlier report showed that the ectopic expression of psNTP9 (PS), a chromatin-associated pea (Pisum sativum) apyrase ...
Manas K. Tripathy, Huan Wang, Robert D. Slocum, Han-Wei Jiang, Ji-Chul Nam, Tanya Sabharwal, Roopadarshini Veerappa, Katherine A. Brown, Katherine A. Brown, Xingbo Cai, Peter Allen Faull, Greg Clark, Stanley J. Roux   +12 more
doaj   +1 more source

Overwhelming mutations or SNPs of SARS-CoV-2: A point of caution

, 2020
Naveen Vankadari
openalex   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Point mutations of Dicer2 conferred Fusarium asiaticum resistance to RNAi-related biopesticide

Journal of Integrative Agriculture
The use of RNA interference (RNAi) technology to control pests is explored by researchers globally. Even though RNA is a new class of pest control compound unlike conventional chemical pesticides, the evolution of pest resistance needs to be considered ...
Kaixin Gu, Ran Wei, Yidan Sun, Xiaoxin Duan, Jing Gao, Jianxin Wang, Yiping Hou, Mingguo Zhou, Xiushi Song   +8 more
doaj   +1 more source

A Point Mutation in carR Is Involved in the Emergence of Polymyxin B-Sensitive Vibrio cholerae O1 El Tor Biotype by Influencing Gene Transcription

, 2020
Prosenjit Samanta, Rahul Shubhra Mandal, Rudra Narayan Saha, Sreeja Shaw, Priyanka Ghosh, Shanta Dutta, Amit Ghosh, Daisuke Imamura, Masatomo Morita, Makoto Ohnishi, Thandavarayan Ramamurthy, Asish K. Mukhopadhyay   +11 more
openalex   +2 more sources

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point [PDF]

, 2015
Rachel Darman, Michael Seiler, Anant A. Agrawal, Kian‐Huat Lim, Shouyong Peng, Daniel Aird, Suzanna Bailey, Erica B. Bhavsar, Betty Chan, Simona Colla, Laura Corson, Jacob Feala, Peter Fekkes, Kana Ichikawa, Gregg F. Keaney, Linda Lee, Pavan Kumar, Kaiko Kunii, Crystal MacKenzie, Mark Matijevic, Yoshiharu Mizui, Khin Than Myint, Eun Sun Park, Xiaoling Puyang, Anand Selvaraj, Michael P. Thomas, Jennifer Tsai, John Y. Wang, Markus Warmuth, Hui Yang, Ping Zhu, Guillermo Garcia‐Manero, Richard R. Furman, Lihua Yu, Peter G. Smith, Silvia Buonamici   +35 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Point Mutations and an Intragenic Deletion in LIS1, the Lissencephaly Causative Gene in Isolated Lissencephaly Sequence and Miller-Dieker Syndrome [PDF]

, 1997
Cristiana Lo Nigro, Samuel S. Chong, Ann C. M. Smith, William B. Dobyns, Rosalba Carrozzo, David H. Ledbetter   +5 more
openalex   +1 more source

Supplementary Tables 1-2 from The Relative Contribution of Point Mutations and Genomic Rearrangements in <i>BRCA1</i> and <i>BRCA2</i> in High-Risk Breast Cancer Families

, 2023
Maurizia Dalla Palma, Susan M. Domchek, Jill E. Stopfer, Julie Erlichman, Jill D. Siegfried, Jessica Tigges-Cardwell, Bernard A. Mason, Timothy R. Rebbeck, Katherine L. Nathanson   +8 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source