Results 161 to 170 of about 7,351,528 (349)

Modified pea apyrase has altered nuclear functions and enhances the growth of yeast and Arabidopsis

Frontiers in Plant Science
Apyrases (NTPDases) regulate growth and development in multiple eukaryotic organisms and function in multiple sub-cellular locales. An earlier report showed that the ectopic expression of psNTP9 (PS), a chromatin-associated pea (Pisum sativum) apyrase ...
Manas K. Tripathy, Huan Wang, Robert D. Slocum, Han-Wei Jiang, Ji-Chul Nam, Tanya Sabharwal, Roopadarshini Veerappa, Katherine A. Brown, Katherine A. Brown, Xingbo Cai, Peter Allen Faull, Greg Clark, Stanley J. Roux   +12 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

STRUM: structure-based prediction of protein stability changes upon single-point mutation

Bioinform., 2016
Lijun Quan, Q. Lv, Yang Zhang
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Recurrence of repeat-induced point mutation (RIP) in Neurospora crassa. [PDF]

, 1991
Edward B. Cambareri, M. J. Singer, Eric U. Selker   +2 more
openalex   +1 more source

Point mutation impairs centromeric CENH3 loading and induces haploid plants

Proceedings of the National Academy of Sciences of the United States of America, 2015
Raheleh Karimi-Ashtiyani, Takayoshi Ishii, M. Niessen, N. Stein, Stefan Heckmann, M. Gurushidze, A. Banaei-Moghaddam, J. Fuchs, V. Schubert, Kerstin Koch, Oda Weiss, D. Demidov, Klaus Schmidt, J. Kumlehn, A. Houben   +14 more
semanticscholar   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Defective apoptosis and B‐cell lymphomas in mice with p53 point mutation at Ser 23 [PDF]

, 2004
David MacPherson, Jungho Kim, Teresa S. Kim, Byung Kirl Rhee, Conny Th.M. van Oostrom, Richard A. DiTullio, Monica Venere, Thanos D. Halazonetis, Roderick T. Bronson, Annemieke de Vries, Mark D. Fleming, Tyler Jacks   +11 more
openalex   +1 more source

Supplementary Tables 1-2 from The Relative Contribution of Point Mutations and Genomic Rearrangements in <i>BRCA1</i> and <i>BRCA2</i> in High-Risk Breast Cancer Families [PDF]

, 2023
Maurizia Dalla Palma, Susan M. Domchek, Jill E. Stopfer, Julie Erlichman, Jill D. Siegfried, Jessica Tigges-Cardwell, Bernard A. Mason, Timothy R. Rebbeck, Katherine L. Nathanson   +8 more
openalex   +1 more source