Results 191 to 200 of about 7,351,528 (349)

Fluoroquinolone-resistant Salmonella Paratyphi A

Emerging Infectious Diseases, 2005
Takuya Adachi, Hiroko Sagara, Kenji Hirose, Haruo Watanabe   +3 more
doaj   +1 more source

Supplementary Figure 14 from Activating Point Mutations in the <i>MET</i> Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors [PDF]

Federica Pecci, Seshiru Nakazawa, Biagio Ricciuti, Guilherme Harada, Jessica Lee, Joao V. Alessi, Adriana Barrichello, Victor R. Vaz, Giuseppe Lamberti, Alessandro Di Federico, Malini Gandhi, Dimitris Gazgalis, William W. Feng, Jie Jiang, Simon Baldacci, Marie-Anaïs Locquet, Felix H. Gottlieb, Monica F. Chen, Elinton Lee, Danielle Haradon, Anna Smokovich, Emma Voligny, Tom Nguyen, Vikas K. Goel, Zachary Zimmerman, Sumandeep Atwal, Xinan Wang, Magda Bahcall, Rebecca S. Heist, Sumaiya Iqbal, Nishant Gandhi, Andrew Elliott, Ari M. Vanderwalde, C. Patrick, Balázs Halmos, Stephen V. Liu, Jianwei Che, Alexa B. Schrock, Alexander Drilon, Pasi A. Jänne, Mark M. Awad   +40 more
openalex   +1 more source

BCR‐ABL exon 7 deletion and novel point mutation in patient with chronic myelogenous leukemia [PDF]

, 2019
Irina Nemchenko, О. В. Нестерова, I. А. Mikhailov, Ilya Mikhailov   +3 more
openalex   +1 more source

Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

Leukemia, 2014
Jon A. Oyer, Xiaoxiao Huang, Yupeng Zheng, J. Shim, T. Ezponda, Zachary Carpenter, Maddalena Allegretta, C. Okot-Kotber, Jay P. Patel, Ari Melnick, Ross L. Levine, Adolfo A. Ferrando, Alexander D. MacKerell, Neil L. Kelleher, Jonathan D. Licht, R. Popovic   +15 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Lenvatinib after progression on pemigatinib and futibatinib in FGFR2 fusion-positive biliary tract cancer with an acquired kinase point mutation. [PDF]

Oncologist
Kleinhenz F, Pfarr N, Steinhelfer L, Lörsch AM, Bendz H, Friedrich M, Liesenfeld L, Barroux M, Maurer C, Wenzel P, Kestler A, Koppermann ML, Mogler C, Spahn S, Illert AL, Schmid RM, Bitzer M, Lange S.   +17 more
europepmc   +1 more source

How a Single-Point Mutation in Horseradish Peroxidase Markedly Enhances Enantioselectivity

, 2009
Eugene Antipov, Art E. Cho, Alexander M. Klibanov   +2 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mismatch-introduced crRNA guided PCR-CRISPR/Cas12a platform improves EGFR point mutation detection in single tumor cell. [PDF]

Mikrochim Acta
Wu M, Wang F, Wang Y, Wu YX, Tian BY, Ou XY, Xu QC, Wu XY, Han C, Liu WL, Xing S.   +10 more
europepmc   +1 more source

A Novel Point Mutation of the RET Proto-oncogene in Small Cell Lung Carcinoma Cell Lines.

, 1994
Hitoyasu Futami, Shinichi Egawa, Ken Yamaguchi   +2 more
openalex   +2 more sources