Results 101 to 110 of about 9,987,835 (286)

Antimicrobial utilization among hospitalized patients according to WHO AWaRe classification: Results from a multicentre point prevalence survey in Saudi Arabia

Journal of Global Antimicrobial Resistance
Background: Antimicrobial resistance (AMR) threatens global health by reducing the efficacy of common infection treatments. This study examines antimicrobial use in Saudi Arabian hospitals, identifies influencing factors, and proposes interventions using
Nada A. Alsaleh, Abeer AlSmari, Abrar F. Alhameed, Ahmed O. Alenazi, Alaa A. Alsharif, Amal Bin Akresh, Anwar M. Alnakhli, Bashaier Alshehail, Eman A. Alzahrani, Ghadah H. Alshehri, Ghazwa B. Korayem, Hanan A. Bakri, Khalid Eljaaly, Lina I. Alnajjar, Norah S. Aldeghaither, Reem Almahasna, Sara Almuhisen, Yassmin Alsomali, Zikria Saleem   +18 more
doaj   +1 more source

Point prevalence survey of antibiotic use in 26 Saudi hospitals in 2016

Journal of Infection and Public Health, 2019
To evaluate the antibiotic prescribing trends, qualitatively and quantitatively, among Saudi Ministry of Health (MOH) hospitals.In May 2016, information about the hospitals and patients was collected for all inpatients from 26 MOH hospitals in Saudi Arabia. Additional information about antibiotic treatment and infections was gathered.
Maher Al Matar, Mushira Enani, Ghada Binsaleh, Hala Roushdy, Deema Alokaili, Amira Al Bannai, Yasser Khidir, Hail Al-Abdely   +7 more
openaire   +3 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Prevalence of epilepsy in Rwanda: a national cross-sectional survey.

, 2008
OBJECTIVE: To estimate the prevalence of epilepsy in Rwanda, as part of a survey of musculoskeletal impairment (MSI). METHODS: Cross-sectional nationally representative survey.
Kuper, Hannah, Simms, V, Rischewski, D, Lavy, C, Nuhu, Assuman, Lavy, Christopher, Kuper, H, Nuhu, A, Atijosan, O, Rischewski, Dorothea, Atijosan, Oluwarantimi, Simms, Victoria   +11 more
core   +1 more source

Application of an updated methodology to estimate the burden of healthcare-associated infections in Italy, 2022

Eurosurveillance
Background Accurate burden estimates are necessary to inform priority setting and rational resource allocation. Weighting prevalence inversely proportional to time-at-risk has been proposed as a solution for length-biased sampling, an important ...
Italian PPS network
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Survey of antibiotic use at a tertiary care hospital in Mexico

Salud Pública de México
Objective. To analyze antibiotic use in a tertiary care hospital in Mexico. Materials and methods. We conducted two point prevalence surveys based on the World Health Organization methodology in a tertiary care hospital in Guadalajara, Mexico.
Federico A Zumaya-Estrada, Hilda Ivonne Huerta-Icelo, Estaban González-Díaz, María del Rayo Morfín-Otero, Jesús Ulises Garza-Ramos, Celia Mercedes Alpuche-Aranda   +5 more
doaj   +1 more source