Results 111 to 120 of about 9,987,835 (286)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Attributable mortality to healthcare-associated infections: a comprehensive nationwide assessment in Spain, 2022 and 2023

Eurosurveillance
BACKGROUND Few studies have quantified mortality caused by healthcare-associated infections (HAIs) of all types. AIM This work’s objective was to estimate the overall impact of HAIs on mortality in Spain.
on behalf of EPINE Study Group
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Establishing an antimicrobial stewardship centre of excellence: A global health partnership between KNUST University hospital & Ulster University

Journal of Global Antimicrobial Resistance
AIM: To create a sustainable global-health antimicrobial stewardship (AMS) focused partnership between Ulster University and Kwame Nkrumah University of Science and Technology (KNUST) University-hospital, enhancing clinical practices and patient outcomes.
Aaron J Courtenay, Ahmed Abuelhana, Jaquie Hanley, Kwame Ayisi Boateng, Obed Amponsah   +4 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Antibiotic use and resistance patterns at Rumphi District Hospital in Malawi: a cross-sectional study

BMC Infectious Diseases
Background Overuse of antibiotics is a key driver of antimicrobial resistance (AMR) world-wide. Malawi continues to report rising cases of AMR among both in-patients and out-patients.
Brany Mithi, Mosen Luhanga, Felix Kaminyoghe, Francis Chiumia, Daniel L. Banda, Lottie Nyama   +5 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Point Cloates, Western Australia [cartographic material].

, 1942
1st ed. "Printed by A.H.Q. Cartographic Company 1942."; Catalogue record generated as part of a batch load.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map ...
Australia. Army. Survey Corps.
core  

Validation of Administrative Data and Timing of Point Prevalence Surveys for Antibiotic Monitoring

JAMA Network Open
ImportancePoint prevalence surveys (PPSs) are used globally to collect data on antibiotic prescriptions. However, the optimal frequency for data collection to ensure comprehensive understanding of antibiotic use and to target and monitor stewardship interventions remains unknown.ObjectiveTo identify the optimal frequency for collecting data on ...
Boracchini, Riccardo, Brigadoi, Giulia, Barbieri, Elisa, Liberati, Cecilia, Rossin, Sara, Tesser, Francesca, Chiusaroli, Lorenzo, Demarin, Giulia Camilla, Maestri, Linda, Tirelli, Francesca, Giaquinto, Carlo, Da Dalt, Liviana, Bressan, Silvia, Cantarutti, Anna, Donà, Daniele   +14 more
openaire   +4 more sources