Results 111 to 120 of about 354,307 (294)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Integrated Household Survey, April 2010 - March 2011

, 2012
copyright UK Data Service and data collection copyright owner.The Integrated Household Survey (IHS), which ran from 2009-2014, was a composite survey combining questions asked on a number of social surveys conducted by the Office for National Statistics (
Office for National Statistics, Social Survey Division
core   +1 more source

Point prevalence of healthcare-associated infections and antibiotic use in three large Swiss acute-care hospitals. [PDF]

, 2018
BACKGROUND The overall burden of healthcare-associated infections (HAIs) remains high, even in high-income countries. However, the current burden of HAI in Switzerland is unknown.
Pittet, Didier, Voide, Cathy, Metsini, Aliki, Vázquez, Miriam, Gardiol, Céline, Zingg, Walter, Marschall, Jonas, Troillet, Nicolas, Sommerstein, Rami   +8 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Attributable mortality to healthcare-associated infections: a comprehensive nationwide assessment in Spain, 2022 and 2023

Eurosurveillance
BACKGROUND Few studies have quantified mortality caused by healthcare-associated infections (HAIs) of all types. AIM This work’s objective was to estimate the overall impact of HAIs on mortality in Spain.
on behalf of EPINE Study Group
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Integrated Household Survey, January - December, 2011

, 2012
copyright UK Data Service and data collection copyright owner.The Integrated Household Survey (IHS), which ran from 2009-2014, was a composite survey combining questions asked on a number of social surveys conducted by the Office for National Statistics (
Office for National Statistics, Social Survey Division
core   +1 more source

Survey of antibiotic use at a tertiary care hospital in Mexico

Salud Pública de México
Objective. To analyze antibiotic use in a tertiary care hospital in Mexico. Materials and methods. We conducted two point prevalence surveys based on the World Health Organization methodology in a tertiary care hospital in Guadalajara, Mexico.
Federico A Zumaya-Estrada, Hilda Ivonne Huerta-Icelo, Estaban González-Díaz, María del Rayo Morfín-Otero, Jesús Ulises Garza-Ramos, Celia Mercedes Alpuche-Aranda   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

A six-years point prevalence survey of healthcare-associated infections in an Italian hospital

, 2019
Healthcare-Associated Infections (HAIs) are among the most serious public health problems in Europe representing the most frequent adverse event during care delivery.
Vallone, Doriana, Damiani, Gianfranco, Ricciardi, Walter, Cambieri, Andrea, Gentili, Andrea, Laurenti, Patrizia, Berloco, Filippo, Di Pumpo, Marcello   +7 more
core   +1 more source