Results 121 to 130 of about 354,307 (294)

Antibiotic use among hospitalized patients in northern Nigeria: a multicenter point- prevalence survey

, 2020
Background: The evaluation of antibiotic use among hospitalized patients is a primary step required to design antibiotic stewardship intervention. There is paucity of data describing antibiotic use in hospitals across Northern Nigeria.
Abubakar, Usman
core   +1 more source

Exploration of the use of antibiotics in a hospital based on point prevalence survey

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To analyze the changes in the use of antibiotics in a tertiary hospital in Jiangsu Province, so as to provide reference for the improvement of antimicrobial drug management in the hospital.Methods·The point prevalence survey was conducted to ...
WANG Kexuan, LIU Fang, TU Jiajia, MAO Yiping   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Australia-wide Point Prevalence Survey of Antimicrobial Prescribing in Neonatal Units: How Much and How Good?

, 2015
There is increasing recognition of the threat to neonatal patients from antibiotic resistance. There are limited data on antimicrobial prescribing practices for hospitalized neonates.
Francis, Joshua R, Blyth, Christopher C, Britton, Philip N, Bryant, Penelope A, Osowicki, Joshua, Cooper, Celia M, Noronha, Jesuina, Nourse, Clare, Gwee, Amanda, Isaacs, David, Lai, Tony B, Avent, Minyon, Moriarty, Paul   +12 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Antibiotic use and resistance patterns at Rumphi District Hospital in Malawi: a cross-sectional study

BMC Infectious Diseases
Background Overuse of antibiotics is a key driver of antimicrobial resistance (AMR) world-wide. Malawi continues to report rising cases of AMR among both in-patients and out-patients.
Brany Mithi, Mosen Luhanga, Felix Kaminyoghe, Francis Chiumia, Daniel L. Banda, Lottie Nyama   +5 more
doaj   +1 more source

Antimicrobial utilization among hospitalized patients according to WHO AWaRe classification: Results from a multicentre point prevalence survey in Saudi Arabia

Journal of Global Antimicrobial Resistance
Background: Antimicrobial resistance (AMR) threatens global health by reducing the efficacy of common infection treatments. This study examines antimicrobial use in Saudi Arabian hospitals, identifies influencing factors, and proposes interventions using
Nada A. Alsaleh, Abeer AlSmari, Abrar F. Alhameed, Ahmed O. Alenazi, Alaa A. Alsharif, Amal Bin Akresh, Anwar M. Alnakhli, Bashaier Alshehail, Eman A. Alzahrani, Ghadah H. Alshehri, Ghazwa B. Korayem, Hanan A. Bakri, Khalid Eljaaly, Lina I. Alnajjar, Norah S. Aldeghaither, Reem Almahasna, Sara Almuhisen, Yassmin Alsomali, Zikria Saleem   +18 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source