Results 121 to 130 of about 9,987,835 (286)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Aurukun [cartographic material] : Queensland topographic survey /

, 1963
1st ed. Topographic map of Aurukun in Queensland showing roads, tracks, telephone lines, astronomical stations, building yards, post offices, schools, police stations, windpumps and landing grounds.
Queensland. Survey Office.
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Ordnance Survey of Northern Ireland [cartographic material] /

, 1965
Various GSGS editions. Topographic map series of Northern Ireland with relief shown by contours, spot heights and hypsometric tints.; Military edition of original civilian series (published from 1960), with grid values and additional marginalia ...
Great Britain. Directorate of Military Survey.
core  

Point-prevalence surveys of hospital-acquired infections in 42 Chinese hospitals in Weifang, China: from 2015 to 2020

BMC Infectious Diseases
Background Hospital-acquired infections (HAIs) are a major health challenge, especially for developing countries. Therefore, this study investigated the prevalence of HAIs in 42 Chinese hospitals in Weifang, China.
Yu Dong, Hongqing Liu
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Holroyd [cartographic material] : Queensland topographic survey /

, 1963
1st ed. Topographic map of Holroyd in Queensland showing roads, tracks, telephone lines, astronomical stations, building yards, post offices, schools, police stations, windpumps and landing grounds.
Queensland. Survey Office.
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Weipa [cartographic material] : Queensland topographic survey /

, 1963
1st ed. Topographic map of Weipa in Queensland showing roads, tracks, telephone lines, astronomical stations, building yards, post offices, schools, police stations, windpumps and landing grounds. Relief shown by hachures and spot heights.; Dyeline print.
Queensland. Survey Office.
core  

Point-prevalence of healthcare-associated infections and antimicrobial use in a tertiary hospital in Shanghai, China: 2012–2023

Antimicrobial Resistance and Infection Control
Background Healthcare-associated infections (HAIs) are a global public health issue and a major threat to patient safety. This study aimed to estimate the prevalence of HAIs and antimicrobial use in a tertiary hospital in Shanghai, China.
Ya Yang, Ruihong Shen, Feng Lu, Bingchao Cai, Mei Huang, Jiayan Ding, Yayun Yuan, Xiaobo Gui, Sijin Yan, Luyao Li, Shiwen Huang, Xiaofang Fu, Haiqun Ban, Xingrong Gong, Zheng Wang   +14 more
doaj   +1 more source