Results 181 to 190 of about 10,528,015 (255)

Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function. [PDF]

Nat Commun
You X, Fan Z, Zhang H, Xie Z, Li C, Gui H, Zou G, Zhan Q, Liu J, Liu X, Zhang D.   +10 more
europepmc   +1 more source

Joint Estimation of Trajectory and Model Parameters for Single Particle Tracking of 3D Confined Diffusion Using the Double-Helix Point Spread Function. [PDF]

IFAC Pap OnLine, 2021
Lin Y, Sharifi F, Andersson SB.
europepmc   +1 more source

Generalizing Ripley's K function to inhomogeneous populations [PDF]

In spatial statistics, Ripley's K function (Ripley, 1977) is a classical tool to analyse spatial point patterns. Yet, it faces two major limits: it is only pertinent for homogeneous point processes and it does not allow the weighting of points.We ...
Florence Puech, Eric Marcon
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Deformable detection transformers for domain adaptable ultrasound localization microscopy with robustness to point spread function variations. [PDF]

Sci Rep
Gharamaleki SK, Helfield B, Rivaz H.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Point spread function estimation with computed wavefronts for deconvolution of hyperspectral imaging data. [PDF]

Sci Rep
Zabic M, Reifenrath M, Wegner C, Bethge H, Landes T, Rudorf S, Heinemann D.   +6 more
europepmc   +1 more source

PCA denoising and Wiener deconvolution of ³¹ P 3D CSI data to enhance effective SNR and improve point spread function. [PDF]

Magn Reson Med, 2021
Froeling M, Prompers JJ, Klomp DWJ, van der Velden TA.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source