Results 61 to 70 of about 61,385 (293)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Vortex equilibria in flow past a plate [PDF]
, 2008 Families of vortex equilibria, with constant vorticity, in steady flow past a flat plate are computed numerically. An equilibrium configuration, which can be thought of as a desingularized point vortex, involves a single symmetric vortex patch located ...
McDonald, NR
core
Multiobjective Hydraulic Design and Performance Analysis of a Vortex Pump Based on Orthogonal Tests
Shock and Vibration, 2021 We design optimization on the overall blade structure of a vortex pump conducted by using the orthogonal test method to clarify the matching relationship of impeller and casing structures and then improve the hydraulic performance of the vortex pump ...
Hui Quan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Simplified model for helical vortex dynamics in the wake of an asymmetric rotor
Flow, 2023 Helical vortex systems, such as those found in the wakes of wind turbines, helicopter rotors and propellers, are subject to instabilities that lead to pairing between adjacent vortex loops.
Aliza Abraham +2 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
A constrained vortex model with relevance to helicopter vortex ring state [PDF]
, 2005 A planar model of a lifting surface descending into its own wake is constructed with the aim of demonstrating some underlying mechanisms of the ‘vortex ring’ state that may be enteredby a rotary wing aircraft during a vertical descent.
Sandham, N.D.
core
Singularity formation in the strongly nonlinear wide-vortex/Tollmien-Schlichting-wave interaction equations [PDF]
, 1999 Published ...
Patel,R.A., Walton,A.G.
core +1 more source
Generalized point vortex dynamics on $CP ^2$
Journal of Geometric Mechanics, 2018 This is the second of two companion papers. We describe a generalization of the point vortex system on surfaces to a Hamiltonian dynamical system consisting of two or three points on complex projective space CP^2 interacting via a Hamiltonian function depending only on the distance between the points. The system has symmetry group SU(3).
Montaldi, James, Shaddad, Amna
openaire +2 more sources
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source