Results 121 to 130 of about 78,267 (285)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Impact of Pointing Errors on the Performance of IRS-Assisted Multi-User THz-NOMA

This paper considers an intelligent reflecting surface (IRS)-assisted multi-user non-orthogonal multiple access (NOMA) system operating in the terahertz band.
Khel, Ahmad Massud Tota, Altuwairgi, Khaled Humaid; id_orcid, Wen, Han; id_orcid, Hamdi, Khairi Ashour; id_orcid   +3 more
core   +1 more source

Using differential signalling to mitigate pointing errors effect in FSO communication link

, 2016
In this paper, we investigate a differential signalling (DS) scheme to mitigate pointing errors effect in intensity-modulation/direct-detection (IM/DD) free space optical (FSO) communication systems with the non-return-to-zero on-off keying (NRZ-OOK ...
Ali-Reza Maheri, Maheri, Alireza, Mansour Abadi, Mojtaba, Mohammad-Ali Khalighi, Ghassemlooy, Zabih, Bhatnagar, Manav R., Zvanovec, Stanislav, Maheri, Ali, Bhatnagar, Manav, Mojtaba Mansour Abadi, Khalighi, Mohammad-Ali, Manav R. Bhatnagar, Khalighi, Mohammad Ali, Zabih Ghassemlooy, Stanislav Zvanovec   +14 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Performance characterization of rotary wing UAV-mounted fso links in the presence of pointing errors

Non-terrestrial networks (NTNs) involve the use of unmanned aerial vehicles (UAVs), high-altitude platform stations (HAPSs), and low-earth orbit satellites (LEOs) and have emerged as a powerful tool to enable global connectivity.
Elamassie, Mohammed, Uysal, Murat
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Cascaded and Sum of Cascaded Over $\boldsymbol{\alpha }$–$\boldsymbol{\mathcal {F}}$ Fading Channels With Pointing Error Impairment

IEEE Open Journal of Vehicular Technology
In this article, exact expressions are presented for the probability density function, cumulative distribution function, moment generating function, and higher-order moments of the instantaneous signal-to-noise ratio, considering the product and the sum ...
Pedro H. D. Almeida, Hugerles S. Silva, Ugo S. Dias, Rausley A. A. de Souza, Iguatemi E. Fonseca, Yonghui Li   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Multihop Free-Space Optical Communications Over Turbulence Channels with Pointing Errors using Heterodyne Detection

, 2014
This paper proposes and analyzes the performance of the multihop free-space optical (FSO) communication links using a heterodyne differential phase-shift keying modulation scheme operating over a turbulence induced fading channel.
Ghassemlooy, Zabih, Wang, Zhaocheng, Xu, Zhengyuan, Tang, Xuan   +3 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source