Results 111 to 120 of about 1,118,680 (286)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The VLT/ERIS vortex coronagraph: design, pointing control, and on-sky performance [PDF]

editorial reviewedThe Enhanced Resolution Imager and Spectrograph (ERIS) is the new near-infrared instrument at the VLT-UT4. ERIS replaces and extends the observational capabilities formerly provided by SINFONI and NACO: integral field spectroscopy at 1 -
Quanz, Sascha P., Huby, E., Grani, Paolo, Puglisi, Alfio, Grani, P., Bonse, Markus, Zins, Gérard, Glauser, Adrian M., Kenworthy, Matt, Dannert, F., Baruffolo, A., Absil, O., Hayoz, J., Glauser, A.M., Salasnich, Bernardo, Huby, Elsa, Puglisi, A., Bonse, M.J., Dannert, Felix, Davies, R., Quanz, S.P., Absil, Olivier, Baruffolo, Andrea, De Rosa, R.J., Kenworthy, M.A., Orban De Xivry, Gilles, Davies, Ric, Taylor, William, Hayoz, Jean, Salasnich, B., Taylor, W., De Rosa, Robert, Orban de Xivry, G., Zins, G.   +33 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Modeling crosstalk coefficients in orbital angular momentum-multiplexed fso channels under gaussian pointing errors

Crosstalk coefficients induced by pointing errors pose a significant challenge in orbital angular momentum (OAM)-multiplexed free space optical (FSO) communication systems. This paper presents a detailed investigation into the impact of Gaussian pointing
Yaseen, M., Elamassie, Mohammed, Uysal, M., Ikki, S. S.   +3 more
core   +1 more source

Error in Key Points [PDF]

JAMA Network Open, 2021
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A novel testing method of beam pointing accuracy for high-power laser facility

Nuclear Engineering and Technology
Pointing shots are typically used to test the beam pointing accuracy of high-power laser facilities. This paper proposes a new method for measuring pointing accuracy by utilizing visible light generated during the low-energy laser interaction with a test
Xiaolu Zhang, Lu Zhang, Song Gao, Huaiwen Guo, Jun Zhang, Junpu Zhao, Pin Yang, Longfei Jing, Ping Li, Wei Zhou   +9 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Operation altitude optimization of airborne FSO links in the presence of pointing errors

With its ultra-high capacity, free space optical (FSO) communication is an ideal backhaul solution for non-terrestrial networks (NTNs). Unlike traditional terrestrial FSO systems, airborne FSO terminals are subject to significant pointing errors.
Elamassie, Mohammed, Uysal, Murat
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source