Results 101 to 110 of about 78,267 (285)

Mixed mmWave RF/FSO Relaying Systems Over Generalized Fading Channels With Pointing Errors

IEEE Photonics Journal, 2017
This paper studies the performance of mixed millimeter-wave radio-frequency (mmWave RF), free-space optics (FSO) systems in a highly scalable and cost-effective solution for fifth-generation (5G) mobile backhaul networks.
Phuc V. Trinh, Truong Cong Thang, Anh T. Pham   +2 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Operation altitude optimization of airborne FSO links in the presence of pointing errors

With its ultra-high capacity, free space optical (FSO) communication is an ideal backhaul solution for non-terrestrial networks (NTNs). Unlike traditional terrestrial FSO systems, airborne FSO terminals are subject to significant pointing errors.
Elamassie, Mohammed, Uysal, Murat
core   +1 more source

What do pointing errors really tell us about internal coordinate transformations

, 1992
Cruse H, Dean J. What do pointing errors really tell us about internal coordinate transformations. Behavioral and Brain Sciences.
J. Dean, H. Cruse, Dean, Jeffrey, Cruse, Holk   +3 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Impact of Pointing Errors on the Performance of Coherent Free-Space Optical Systems

, 2016
In this letter, we investigate the performance of a coherent free-space optical (FSO) communications system considering geometric spread and pointing errors as well as atmospheric turbulence fading and path loss.
Park, Jaedon, Lee, Eunju, Chae, Chan Byoung, Yoon, Gi-Wan   +3 more
core   +1 more source

CDMA RoFSO Links With Nonzero Boresight Pointing Errors Over M Turbulence Channels

IEEE Photonics Journal, 2018
Radio-on-Free-Space Optical systems constitute a very attractive option for interconnecting central base stations with remote antenna units. Nonetheless, the optical signal propagation through the atmosphere is tremendously affected by turbulence- and ...
Michalis P. Ninos, Hector E. Nistazakis, Harilaos G. Sandalidis, George S. Tombras   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source