Results 101 to 110 of about 1,118,680 (286)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Mixed mmWave RF/FSO Relaying Systems Over Generalized Fading Channels With Pointing Errors
IEEE Photonics Journal, 2017 This paper studies the performance of mixed millimeter-wave radio-frequency (mmWave RF), free-space optics (FSO) systems in a highly scalable and cost-effective solution for fifth-generation (5G) mobile backhaul networks.
Phuc V. Trinh +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Pointing Errors Reflect Biases in the Perception of the InitialHand Position
, 1998 Vindras, Philippe, Michel Desmurget, Claude Prablanc, and Paolo Viviani. Pointing errors reflect biases in the perception of the initial hand position. J. Neurophysiol. 79: 3290–3294, 1998.
Michel Desmurget +3 more
core +1 more source
Pointing errors in immediate and delayed conditions in unilateral optic ataxia.
, 2003 International audienceThe present paper provides an analysis of the pointing errors of a patient with unilateral optic ataxia (O.K.) following right hemispheric damage, revealing the type of errors related tothe use of the contralesional hand and/or to ...
Rode, G. +5 more
core +5 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Estimation of Pointing Errors of Large Radio Telescopes under Solar Radiation Based on Digital Twin
The pointing accuracy of large radio telescopes is affected by antenna structure errors, installation errors, servo errors, gravity, and varying environmental factors.
Yongxiang Li +7 more
core +1 more source
CDMA RoFSO Links With Nonzero Boresight Pointing Errors Over
IEEE Photonics Journal, 2018 Radio-on-Free-Space Optical systems constitute a very attractive option for interconnecting central base stations with remote antenna units. Nonetheless, the optical signal propagation through the atmosphere is tremendously affected by turbulence- and ...
Michalis P. Ninos +3 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source