Results 91 to 100 of about 1,118,680 (286)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Performance comparison between uniformly and nonuniformly spaced adaptive antennas with respect to tolerance to pointing errors

, 2006
The paper presents theoretical and experimental investigations into performances of narrowband uniformly and nonuniformly spaced adaptive linear dipole array antennas that are subjected to pointing errors.
Homer, J. P., Bialkowski, M. E., Al-Ka'bi, A. H.   +2 more
core   +1 more source

Performance Analysis of IRS-Assisted THz Communication Systems over α-μ Fading Channels with Pointing Errors. [PDF]

Sensors (Basel), 2023
Alvi SH, Ali B, Mirza J, Javed MA, Fida A, Lee BM, Bashir T.   +6 more
europepmc   +1 more source

Outage Probability of Mixed THz-UWOC Transmission Systems With Hardware Impairments

IEEE Access
In this paper, we propose a mixed dual-hop communication system consisting of terahertz/underwater wireless optical communication (THz-UWOC) links with hardware impairments. In particular, considering the heterodyne detection, we assume that the THz link
Shenghai Chen, Lili Wan, Xianwu Mi
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Efficient Uncertainty Quantification for Satellite Antenna Pointing: A GSA-PEM Framework Integrating Multi-Source Disturbances

Aerospace
Space-borne antenna pointing is affected by uncertain disturbances like satellite attitude, structural flexibility, and manufacturing/installation errors. Understanding the effect of these uncertainties is crucial for antenna performance.
Shiyu Tan, Ning Zhang, Yingyong Shen, Cong Wang, Jingbo Gao   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Errors and learning from errors at work

, 2012
To understand what constitutes errors at work and, in particular, how productive learning might arise from those errors, it is necessary to go beyond viewing errors as only objective social facts.
Billett, Stephen, Billett, S, Stephen Billett   +2 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Improved beamforming for FSO MISO system over gamma-gamma fading with pointing errors

, 2016
International audienceIn this paper, we study the problem of feedback based beamforming for multiple-input single-output free space optical (FSO) system with pointing errors.
Bhatnagar, Manav R., Ankit Garg, Olivier Berder, Vrigneau, Baptiste, Manav R. Bhatnagar, Berder, Olivier, Garg, Ankit, Baptiste Vrigneau   +7 more
core   +1 more source