Results 91 to 100 of about 78,267 (285)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2023 This letter focuses on providing an analytical framework for the quantification and evaluation of high-directional terahertz communication links under pointing errors in terms of outage probability (OP), channel capacity, and symbol error rate (SER).
Hasna, Mazen +2 more
core +1 more source
AerospaceSpace-borne antenna pointing is affected by uncertain disturbances like satellite attitude, structural flexibility, and manufacturing/installation errors. Understanding the effect of these uncertainties is crucial for antenna performance.
Shiyu Tan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Crosstalk coefficients induced by pointing errors pose a significant challenge in orbital angular momentum (OAM)-multiplexed free space optical (FSO) communication systems. This paper presents a detailed investigation into the impact of Gaussian pointing
Yaseen, M. +3 more
core +1 more source
Experimental investigation of pointing errors on drone-based FSO systems
, 2020 Airborne free space optical (FSO) links can be efficiently used for backhaul/fronthaul needs of future cellular networks. Unlike terrestrial FSO links where a fixed connection between two buildings is considered, airborne FSO links bring unique ...
Hatef Nouri +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
CORRELATED ERRORS IN EARTH POINTING MISSIONS
, 2005 Two different Earth-pointing missions dealing with attitude control and dynamics changes illustrate concerns with correlated error sources and coupled effects that can occur. On the OrbView-2 (OV-2) spacecraft, the assumption of a nearly-inertially-fixed
Patt, Frederick S., Bilanow, Steve
core