Results 171 to 180 of about 835,873 (364)
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li+24 more
wiley +1 more source
OBSERVATIONS ON 685 CASES OF POISONING BY NOXIOUS GASES USED BY THE ENEMY [PDF]
J. E. Black+2 more
openalex +1 more source
Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation
Multipotent mesenchymal stem cells (MSCs) have high self-renewal and multi-lineage differentiation potentials and low immunogenicity, so they have attracted much attention in the field of regenerative medicine and have a promising clinical application ...
Mengyu Wu+9 more
doaj +1 more source
Cytokine Storm Induction Linked to Multi‐Organ Failure in Fatal Jellyfish Stings
N. nomurai is the most important injurious species in the coastal area of China. Model construction, omics analysis, mechanism exploration, and intervention measures of N. nomurai envenomation are performed in the current study, and it suggested that cytokine storm played an important role in pathogenesis.
Yichao Wang+15 more
wiley +1 more source
Mesenchymal stem cells (MSCs) possess multipotent properties that make them promising candidates for immunomodulation and regenerative medicine. However, MSC heterogeneity poses challenges to their research reproducibility and clinical application.
Miao Yu, Ke Sui, Zheng Wang, Xi Zhang
doaj +1 more source
PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury
Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan+17 more
wiley +1 more source
The practical scale of AEMWE is achieved using waste alkaline water and non‐precious metals for electrolytes and electrocatalysts. Electrocatalysts incorporating Ni with CeO₂ demonstrate EMSI effects, boosting both performance and durability. The AEMWE system, with an active area of 64 cm2, undergoes a 2000‐h durability test, resulting in a low ...
Nam In Kim+16 more
wiley +1 more source