Results 171 to 180 of about 835,873 (364)

A Case of Poisoning [PDF]

open access: yesThe Boston Medical and Surgical Journal
n ...
openaire   +4 more sources

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

open access: yesAdvanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li   +24 more
wiley   +1 more source

Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation

open access: yesCell Transplantation
Multipotent mesenchymal stem cells (MSCs) have high self-renewal and multi-lineage differentiation potentials and low immunogenicity, so they have attracted much attention in the field of regenerative medicine and have a promising clinical application ...
Mengyu Wu   +9 more
doaj   +1 more source

Cytokine Storm Induction Linked to Multi‐Organ Failure in Fatal Jellyfish Stings

open access: yesAdvanced Science, EarlyView.
N. nomurai is the most important injurious species in the coastal area of China. Model construction, omics analysis, mechanism exploration, and intervention measures of N. nomurai envenomation are performed in the current study, and it suggested that cytokine storm played an important role in pathogenesis.
Yichao Wang   +15 more
wiley   +1 more source

MSCsDB: a database of single-cell transcriptomic profiles and in-depth comprehensive analyses of human mesenchymal stem cells

open access: yesExperimental Hematology & Oncology
Mesenchymal stem cells (MSCs) possess multipotent properties that make them promising candidates for immunomodulation and regenerative medicine. However, MSC heterogeneity poses challenges to their research reproducibility and clinical application.
Miao Yu, Ke Sui, Zheng Wang, Xi Zhang
doaj   +1 more source

PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan   +17 more
wiley   +1 more source

Collapsing the Bottleneck by Interfacial Effect of Ni/CeO2 for Long‐Term Hydrogen Production using Waste Alkaline Water in Practical‐Scale Anion Exchange Membrane Water Electrolyzer

open access: yesAdvanced Science, EarlyView.
The practical scale of AEMWE is achieved using waste alkaline water and non‐precious metals for electrolytes and electrocatalysts. Electrocatalysts incorporating Ni with CeO₂ demonstrate EMSI effects, boosting both performance and durability. The AEMWE system, with an active area of 64 cm2, undergoes a 2000‐h durability test, resulting in a low ...
Nam In Kim   +16 more
wiley   +1 more source

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