Results 21 to 30 of about 290,076 (302)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications

Nano-Micro Letters
Highlights A large-scale metabolic adaptation in M1-polarized macrophages compared with M2 macrophages, along with multiple altered metabolite parameters that can serve as potential targets, have been discussed.
Tingting Meng, Danfeng He, Zhuolei Han, Rong Shi, Yuhan Wang, Bibo Ren, Cheng Zhang, Zhengwei Mao, Gaoxing Luo, Jun Deng   +9 more
doaj   +1 more source

Epidemiology, clinical presentation, treatment, and follow‐up of chronic mercury poisoning in China: a retrospective analysis

BMC Pharmacology and Toxicology, 2021
Background There are no reports on the incidence of chronic mercury poisoning in a large population in China. This study investigated the epidemiology, clinical manifestations, treatment, and follow-up of Chinese patients with chronic mercury poisoning ...
Sun Yawei, Long Jianhai, Zhao Junxiu, Peng Xiaobo, Qiu Zewu   +4 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Behavior characteristics of peer reviewers in medical journals: a survey from China

Research Integrity and Peer Review
Background Peer review is fundamental to quality scientific communication, yet reviewer behavior remain underexplored. The impact of emerging large language models (LLMs) on peer review practices is similarly understudied.
Guie Liu, Yuan Tian, Jing Peng, Lianyang Zhang, Lei Li   +4 more
doaj   +1 more source

A case of accidental Ricin poisoning [PDF]

, 2004
A case report of accidental, mild ricin poisoning by ingestion of ten Castor beans by a 70 year old man. The clinical presentation is followed by a discussion about the toxicity of ricin, its use and misuse and the contrast between the toxicity of pure ...
Despott, Edward, Cachia, Mario J.
core  

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

A combination of selenium and Bacillus subtilis improves the quality and flavor of meat and slaughter performance of broilers

Frontiers in Veterinary Science, 2023
This study aimed to investigate the effects of the combination of selenium and Bacillus subtilis (Se-BS) on the quality and flavor of meat and slaughter performance of broilers.
Jihong Dong, Huiling Qiu, Huiling Qiu, Shansong Gao, Lele Hou, Huawei Liu, Huawei Liu, Lianqin Zhu, Fu Chen   +8 more
doaj   +1 more source

Lewis Acid Site Engineering in MOF‐Derived Aluminum Oxide/Carbon Composites for Dechlorination of Waste Plastic Pyrolysis Oil

Advanced Functional Materials, EarlyView.
Controlled carbonization of an Al‐MOF partially decomposes its linkers, exposing coordinatively unsaturated Al centers within an oxide/carbon composite. The resulting Lewis acid sites, rather than surface area, govern organochlorine capture: the composite removes chemically diverse organochlorines from waste plastic pyrolysis oil, outperforms a ...
Seong Cheon Kim, Byeongju Jeon, Suk Hyun Lim, Eun Hee Kwon, Nam Sun Nho, Siyoung Q. Choi, Jeasung Park   +6 more
wiley   +1 more source

Beyond Presumptions: Toward Mechanistic Clarity in Metal‐Free Carbon Catalysts for Electrochemical H2O2 Production via Data Science

Advanced Materials, EarlyView.
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu, Hsi‐wen Wu, Xiao Wang, Jie Zhang   +3 more
wiley   +1 more source