Results 21 to 30 of about 281,253 (299)

Sepsis-Induced Endothelial Barrier Dysfunction: Mechanisms, Pathology, and Therapeutic Advances

Research
Sepsis is a life-threatening disease characterized by systemic inflammation and endothelial barrier dysfunction, leading to multiorgan failure and high mortality.
Rui Wang, Qiuju Han, Jiangbo Fan, Zhe Xu, Wenyi Liu, Di Liu, You Li, Juan Du, Jianhui Sun, Huacai Zhang, Qingli Cai, Chu Gao, Jianxin Jiang, Zhen Wang, Ling Zeng   +14 more
doaj   +1 more source

A combination of selenium and Bacillus subtilis improves the quality and flavor of meat and slaughter performance of broilers

Frontiers in Veterinary Science, 2023
This study aimed to investigate the effects of the combination of selenium and Bacillus subtilis (Se-BS) on the quality and flavor of meat and slaughter performance of broilers.
Jihong Dong, Huiling Qiu, Huiling Qiu, Shansong Gao, Lele Hou, Huawei Liu, Huawei Liu, Lianqin Zhu, Fu Chen   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications

Nano-Micro Letters
Highlights A large-scale metabolic adaptation in M1-polarized macrophages compared with M2 macrophages, along with multiple altered metabolite parameters that can serve as potential targets, have been discussed.
Tingting Meng, Danfeng He, Zhuolei Han, Rong Shi, Yuhan Wang, Bibo Ren, Cheng Zhang, Zhengwei Mao, Gaoxing Luo, Jun Deng   +9 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Behavior characteristics of peer reviewers in medical journals: a survey from China

Research Integrity and Peer Review
Background Peer review is fundamental to quality scientific communication, yet reviewer behavior remain underexplored. The impact of emerging large language models (LLMs) on peer review practices is similarly understudied.
Guie Liu, Yuan Tian, Jing Peng, Lianyang Zhang, Lei Li   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

A case of accidental Ricin poisoning [PDF]

, 2004
A case report of accidental, mild ricin poisoning by ingestion of ten Castor beans by a 70 year old man. The clinical presentation is followed by a discussion about the toxicity of ricin, its use and misuse and the contrast between the toxicity of pure ...
Despott, Edward, Cachia, Mario J.
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source