Results 161 to 170 of about 10,095 (194)

Enhanced tumor imaging with pokeweed mitogen

Nuclear Medicine and Biology, 1993
Traditional tumor imaging with biotracer techniques relies solely on the target specificity of the biomolecule. We hypothesize that specific imaging is possible by altering the rate of tissue clearance (both normal and aberrant) of any given radiotracer.
D M, Bitner, P L, Mann, P, D'Souza, R, Wenk, D G, Baughman, S M, Quesada, R, Purvis, J L, Born, N A, Matwiyoff, D, Eshima   +9 more
openaire   +2 more sources

Carbohydrate-binding specificity of pokeweed mitogens

Biochimica et Biophysica Acta (BBA) - General Subjects, 1978
The carbohydrate-binding specificity of two pokeweed (Phytolacca americana) mitogens (Pa-1 and Pa-2) was investigated by means of hemagglutination inhibition assays and the quantitative inhibition of the binding of 125I-labeled lectins to human erythrocytes using various oligosaccharides, glycopeptides and glycoproteins as hapten inhibitors.
K, Yokoyama, T, Terao, T, Osawa
openaire   +2 more sources

Anti-pokeweed mitogen antiserum inhibits and enhances blastogenesis of mononuclear cells induced by pokeweed mitogen

Agents and Actions, 1988
The interaction between pokeweed mitogen (PWM) and peripheral blood mononuclear cells (PBMC) was investigated using rabbit anti-PWM antiserum (anti-PWM) and 125I-PWM. Incubation of PBMC with PWM in the presence of anti-PWM resulted in an inhibition of the mitogenic effect of PWM.
H G, Uiterdijk, E, de Vries, J P, van der Weij, H J, Kornman, C J, van der Veen, A, Cats   +5 more
openaire   +2 more sources

Pokeweed Antiviral Protein and Its Applications

2000
The genus Phytolacca produces a number of proteins that have antiviral properties. These antiviral proteins are ribosome-inactivating proteins (RIPs) which remove a single adenine from a highly conserved, surface-exposed, stem-loop structure in the large rRNA of eukaryotic and prokaryotic ribosomes.
N E, Tumer, K, Hudak, R, Di, C, Coetzer, P, Wang, O, Zoubenko   +5 more
openaire   +2 more sources

Identification of the Pokeweed Mitogen in Africa

Nature, 1967
IN 1960, Nowell1 first described a plant lectin from Phaseolus vulgaris—phytohaemagglutinin, which possessed mitogenic activity for human peripheral blood lymphocytes, that is, the ability to transform the resting lymphocyte into blast like cells. Subsequently, a second phytomitogen was reported2 in saline extracts of the plant Phytolacca americana—the
P. R. GLADE, J. A. KASEL, H. MCFARLANE, J. BORJESON, P. D. BAKER, P. F. HOFFMAN, S. D. DOUGLAS, R. REISFELD, L. N. CHESSIN   +8 more
openaire   +2 more sources

Expression of pokeweed antiviral proteins in creeping bentgrass

Plant Cell Reports, 2003
Fungal diseases of creeping bentgrass, an important amenity grass used extensively on golf courses, are a serious problem in golf course management. Transgenic approaches to improving disease resistance to fungal diseases are being explored in many species, and in some cases ribosome-inactivating proteins have been found to be effective.
W D, Dai, S, Bonos, Z, Guo, W A, Meyer, P R, Day, F C, Belanger   +5 more
openaire   +2 more sources

A Geography of Pokeweed

Annals of the Missouri Botanical Garden, 1952
The plants we call weeds stand apart from their truly wild and truly tame fellows because of their special ability to establish themselves in artificial habitats. In spite of indifference or active repression by man, they have been able to thrive and multiply with the advance of civilization.
openaire   +1 more source

Pokeweed antiviral protein: Ribosome inactivation and therapeutic applications

Pharmacology & Therapeutics, 1992
Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP) that inactivates ribosomes by the removal of a single adenine from ribosomal RNA. The studies summarized in our review concern the nature and application of this novel therapeutic agent. We describe how researchers continue to elucidate the structure and biologic activity of RIPs.
J D, Irvin, F M, Uckun
openaire   +2 more sources

Lymphocytenstimulierung durch Pokeweed-Mitogen (PWM)

Klinische Wochenschrift, 1969
Among the substances causing an unspecific stimulation of lymphocytes in vitro pokeweed mitogen (PWM), a glycoprotein isolated from pokeweed (Phytolacca americana L.), is of special interest. Studies performed at the light and electron microscope level have shown the production in vitro by PWM of large phytohemagglutinin (PHA) -like blasts and of a ...
G. Brittinger, E. K�nig
openaire   +1 more source

Cytotoxicity of pokeweed antiviral protein.

Cytobios, 1989
Pokeweed antiviral protein, a plant protein which inactivates eukaryotic ribosomes, was found to be cytotoxic to both HeLa and Vero cells. Cellular protein synthesis was inhibited by exposure of the cells to microM concentrations of the antiviral protein for 24 h periods or longer.
G M, Aron, J D, Irvin
openaire   +1 more source