Results 11 to 20 of about 1,930 (169)

Inhibition of pokeweed antiviral protein (PAP) by turnip mosaic virus genome-linked protein (VPg). [PDF]

J Biol Chem, 2012
Pokeweed antiviral protein (PAP) from Phytolacca americana is a ribosome-inactivating protein (RIP) and an RNA N-glycosidase that removes specific purine residues from the sarcin/ricin loop of large rRNA, arresting protein synthesis at the translocation ...
Domashevskiy AV, Miyoshi H, Goss DJ.
europepmc   +5 more sources

Improved pokeweed genome assembly and early gene expression changes in response to jasmonic acid [PDF]

BMC Plant Biology
Background Jasmonic acid (JA) is a phytohormone involved in regulating responses to biotic and abiotic stress. Although the JA pathway is well characterized in model plants such as Arabidopsis thaliana, less is known about many non-model plants ...
Kyra Dougherty, Tanya Prashar, Katalin A. Hudak   +2 more
doaj   +2 more sources

A novel interaction of pokeweed antiviral protein with translation initiation factors 4G and iso4G: a potential indirect mechanism to access viral RNAs. [PDF]

Nucleic Acids Res, 2006
Pokeweed antiviral protein (PAP) is a ribosome inactivating protein recognized primarily for its ability to depurinate the sarcin/ricin loop of the large rRNA.
Wang M, Hudak KA.
europepmc   +3 more sources

Homodimerization of pokeweed antiviral protein as a mechanism to limit depurination of pokeweed ribosomes. [PDF]

Mol Plant Pathol, 2010
SUMMARY Ribosome inactivating proteins are glycosidases synthesized by many plants and have been hypothesized to serve in defence against pathogens. These enzymes catalytically remove a conserved purine from the sarcin/ricin loop of the large ribosomal RNA, which has been shown in vitro
Tourlakis ME, Karran RA, Desouza L, Siu KW, Hudak KA.   +4 more
europepmc   +4 more sources

Poliovirus-mediated entry of pokeweed antiviral protein. [PDF]

Antimicrob Agents Chemother, 1990
Infection of HeLa cells with poliovirus results in cell permeabilization to pokeweed antiviral protein. Cell permeabilization was dependent on the integrity of virus capsid proteins and directly proportional to the multiplicity of infection. This study demonstrates that virus adsorption is sufficient for the entry of pokeweed antiviral protein into ...
Lee T, Crowell M, Shearer MH, Aron GM, Irvin JD.   +4 more
europepmc   +4 more sources

Antiviral foods in the battle against viral infections: Understanding the molecular mechanism

Food Science &Nutrition, Volume 11, Issue 8, Page 4444-4459, August 2023., 2023
Regular intake of antiviral foods may prevent future pandemic and the use of antiviral food with traditional medicine may reduce the severity of viral diseases. Abstract Viruses produce a variety of illnesses, which may also cause acute respiratory syndrome. All viral infections, including COVID‐19, are associated with the strength of the immune system.
Md. Shofiul Azam, Md. Nahidul Islam, Md. Wahiduzzaman, Mahabub Alam, Akib Atique Khan Dhrubo   +4 more
wiley   +1 more source

T‐cell recovery and evidence of persistent immune activation 12 months after severe COVID‐19

Allergy, Volume 77, Issue 8, Page 2468-2481, August 2022., 2022
In a multicentric cohort of 173 COVID‐19 patients followed‐up to 1 year we found evidence of functional and numeric T cell recovery. COVID‐19 patients showed persistent moderate T cell activation at follow‐up timepoints. A subgroup of severe COVID‐19 patients exhibited low CD8+ T cell counts at follow‐up, coupled to an inflammatory immune signature and
Patrick Taeschler, Sarah Adamo, Yun Deng, Carlo Cervia, Yves Zurbuchen, Stéphane Chevrier, Miro E. Raeber, Sara Hasler, Esther Bächli, Alain Rudiger, Melina Stüssi‐Helbling, Lars C. Huber, Bernd Bodenmiller, Onur Boyman, Jakob Nilsson   +14 more
wiley   +1 more source

Profound dysregulation of T cell homeostasis and function in patients with severe COVID‐19

Allergy, Volume 76, Issue 9, Page 2866-2881, September 2021., 2021
In severe COVID‐19 T cell populations show perturbations, including loss of naïve T cells, CD4+ T cell skewing toward T follicular helper and cytotoxic phenotypes and expansion of activated and exhausted T cells. Apoptosis and migration contribute to the lymphopenia of severe disease, which is accompanied by Interleukin‐7 elevation.
Sarah Adamo, Stéphane Chevrier, Carlo Cervia, Yves Zurbuchen, Miro E. Raeber, Liliane Yang, Sujana Sivapatham, Andrea Jacobs, Esther Baechli, Alain Rudiger, Melina Stüssi‐Helbling, Lars C. Huber, Dominik J. Schaer, Bernd Bodenmiller, Onur Boyman, Jakob Nilsson   +15 more
wiley   +1 more source

Inhibition of hepatitis B virus replication by pokeweed antiviral protein in vitro. [PDF]

World J Gastroenterol, 2008
To explore the inhibitory effects of pokeweed antiviral protein seed (PAP-S) and PAP encoded by a eukaryotic expression plasmid on hepatitis B virus (HBV) replication in vitro.HepG2 2.2.15 cells in cultured medium were treated with different concentrations of PAP-S.
He YW, Guo CX, Pan YF, Peng C, Weng ZH.
europepmc   +3 more sources

Extracellular localization of pokeweed antiviral protein. [PDF]

Proc Natl Acad Sci U S A, 1986
Pokeweed antiviral protein is an enzyme of Mr 29,000 known to inactivate a wide variety of eukaryotic ribosomes. We have used electron microscopy to show that the antibody specific for the protein is bound within the cell wall matrix of leaf mesophyll cells from Phytolacca americana. Any penetration or breakage of the cell wall and membrane could allow
Ready MP, Brown DT, Robertus JD.
europepmc   +4 more sources