Impaired antibody-mediated protection and defective IgA B cell memory in experimental infection of adults with respiratory syncytial virus [PDF]
, 2015 Rationale: Despite relative antigenic stability, respiratory syncytial virus (RSV) re-infects throughout life. After >40 years of research, no effective human vaccine exists and correlates of protection remain poorly defined.
Chiu, C +10 more
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Depurination of plant ribosomes by pokeweed antiviral protein [PDF]
FEBS Letters, 1990 Mammalian ribosomes have been shown to be enzymatically modified by ribosomal inactivating protein (RIPs) via specific depurination of rRNA. Here we report that ribosomes isolated from wheat germ contain intact and undepurinated rRNA and are depurinated by pokeweed antiviral protein (PAP).
Taylor, Blair E., Irvin, James D.
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Pokeweed Antiviral Protein Accesses Ribosomes by Binding to L3 [PDF]
Journal of Biological Chemistry, 1999 Pokeweed antiviral protein (PAP), a 29-kDa ribosome-inactivating protein, catalytically removes an adenine residue from the conserved alpha-sarcin loop of the large rRNA, thereby preventing the binding of eEF-2.GTP complex during protein elongation. Because the alpha-sarcin loop has been placed near the peptidyltransferase center in Escherichia coli ...
K A, Hudak, J D, Dinman, N E, Tumer
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Actions of Pokeweed Antiviral Protein on Virus-infected Protoplasts [PDF]
Bioscience, Biotechnology, and Biochemistry, 1997 Pokeweed antiviral protein (PAP) belongs to a group of ribosome-inactivating proteins (RIPs) that inactivate ribosomes by depurinating rRNA at a specific site. To study the mechanism for the antiviral activity of PAP, the actions of PAP on TMV-infected and uninfected tobacco protoplasts were investigated.
K, Watanabe +3 more
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Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
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Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
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The cytolytic T lymphocyte response to the murine cytomegalovirus [PDF]
, 1984 During the acute cytolytic T lymphocyte (CTL) response of mice to infection with the murine cytomegalovirus two independent populations of activated interleukin-receptive CTL precursors can be demonstrated.
Ada +25 more
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Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina [PDF]
, 2013 Ribosome-inactivating proteins (RIPs) are endowed with several medicinal properties, including antiviral activity. We demonstrate here that the recently identified type I RIP from Momordica balsamina also possesses antiviral activity, as determined by ...
Ahmed, Zahra +5 more
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Antiviral activity of ribosome-inactivating proteins [PDF]
, 2021 Producción CientíficaRibosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis.
Citores González, Lucía +2 more
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The future of antiviral immunotoxins [PDF]
, 2016 There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments.
Høy Jakobsen, Mette +3 more
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